Risk Factors for Cognitive Impairment in Fragile X-Associated Tremor/Ataxia Syndrome

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disease with motor, psychiatric, and cognitive manifestations that occurs in carriers of the fragile X mental retardation 1 (FMR1) gene premutations. This was a retrospective chart review of 196 individuals (127 men and 69 women) with FXTAS. Forty-six (23%) participants were cognitively impaired, of whom 19 (10%) had dementia. Risk factors for dementia were examined (CGG repeat size; alcohol, benzodiazepine, and opioid use; diabetes; hyperlipidemia; hypertension; hypothyroidism; obesity; sleep apnea; surgeries with general anesthesia; depression; family history of dementia). Thirteen individuals with FXTAS and dementia were then compared to 13 cognitively intact individuals matched on age, gender, and FXTAS stage. CGG repeat size was significantly higher (mean = 98.5, standard deviation [SD] = 22.2) in the dementia group, compared to the cognitively intact group (mean = 81.6, SD = 11.5; P = .0256). These results show that CGG repeat size is a risk factor for FXTAS dementia.
Source: Journal of Geriatric Psychiatry and Neurology - Category: Genetics & Stem Cells Authors: Tags: Articles Source Type: research

Related Links:

Publication date: Available online 10 December 2019Source: Trends in Food Science &TechnologyAuthor(s): Roberto Castro-Muñoz, Grzegorz Boczkaj, Emilia Gontarek, Alfredo Cassano, Vlastimil FílaAbstractBackgroundNowadays, membrane-based technologies (e.g. microfiltration, ultrafiltration, nanofiltration, membrane distillation, and pervaporation) have demonstrated to meet the requirements to be involved in different food and bioproduct processes.Scope and approachSeveral applications have been developed, including either separation, recovery or concentration of bioactive molecules from agro-food products and...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
Publication date: April 2020Source: Food Control, Volume 110Author(s): Sira Sansuk, Paramust Juntarakod, Wimonrat Tongphoothorn, Atchara Sirimungkala, Titikan SomboonAbstractA simple chemo-chronometric method utilizing the Belousov-Zhabotinsky (BZ) oscillating reaction for the efficient detection of ethanol in alcoholic beverages has been developed. This visual detecting strategy only required a smartphone, without implemented instrumental detection systems, to video a unique colorimetric alternating (red-to-blue) feature of the BZ solution system containing 0.50 M bromate, 0.12 M malonic acid, 0.03 M bromid...
Source: Food Control - Category: Food Science Source Type: research
Authors: Wietersheim JV, Knoblauch JD, Rottler E, Weiß H, Hartmann A, Rochlitz P, Völker A, Scheidt CE, Beutel ME, Eckhardt-Henn A, Zeeck A Abstract Several therapeutic treatments like individual psychotherapy, group therapy, creative therapies and talks with the nursing staff are components in an inpatient psychosomatic (psychotherapeutic) treatment or a psychosomatic day hospital treatment. In Germany, these therapies have to be documented by the administration with so called OPS-Codes. These codes are reported to the Institute for Reimbursement in Hospitals (InEK). With the data of the INDDEP-study it...
Source: PPmP Psychotherapie Psychosomatik Medizinische Psychologie - Category: Psychiatry & Psychology Tags: Psychother Psychosom Med Psychol Source Type: research
Authors: Priegnitz J, Langheim E, Rademacher W, Schmitz C, Köllner V Abstract An integrative patient-centered care concept is increasingly demanded for treatment of cardiac patients with concomitant mental disorders. The present study aims to investigate the effect of an integrated concept of psycho-cardiac care (PK) versus a monodisciplinary cardiac (K) or psychosomatic (PSO) care. Patients were examined at baseline (T0), at the time of discharge from the rehabilitation program (T1) and after 6 month (T2). General anxiety, depression (HADS), cardiac anxiety (HAF) and quality of life (SF-12) were evaluated usi...
Source: PPmP Psychotherapie Psychosomatik Medizinische Psychologie - Category: Psychiatry & Psychology Tags: Psychother Psychosom Med Psychol Source Type: research
Publication date: Available online 10 December 2019Source: Small Ruminant ResearchAuthor(s): J. Reintke, K. Brügemann, H. Wagner, P. Engel, A. Wehrend, S. KönigAbstractThere is an increasing economic pressure in sheep production. Hence, it is imperative to use all available tools contributing to improvements in lamb survival. In this regard, there is a lack of studies addressing the impact of maternal body condition traits on lamb performances during lactation. Specifically, the focus of the present study was to analyse associations between ewe traits reflecting maternal energy metabolism and lamb body weight (LB...
Source: Small Ruminant Research - Category: Zoology Source Type: research
Conclusion: The results of this randomised controlled trial with assessment of blood pressure and same-day self-reports will provide patients a tool to understand the interplay between blood pressure and lifestyle applicable to primary health care. The self-management support system may be of importance for improved adherence to treatment and persistence to treatment recommendations. PMID: 31814476 [PubMed - as supplied by publisher]
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
Publication date: Available online 11 December 2019Source: Enzyme and Microbial TechnologyAuthor(s): Zhi-Hao Xia, Min-Hua Zong, Ning LiAbstract2,5-Bis(hydroxymethyl)furan (BHMF) is a versatile building block in the synthesis of polymers, fuels, and macrocycle polyethers. In this work, alcohol dehydrogenases (ADHs) were identified from Meyerozyma guilliermondii SC1103 and were heterologously expressed in Saccharomyces cerevisiae for the synthesis of BHMF from 5-hydroxymethylfurfural (HMF). Of recombinant strains constructed, S. cerevisiae expressing an aryl ADH (AAD1669) was observed to be the best catalyst. Upon process op...
Source: Enzyme and Microbial Technology - Category: Biotechnology Source Type: research
Authors: Morita K, Wang D, Baba R, Morimoto H, Song Y, Kanazawa T, Yoshida Y Abstract Although it is known that desert dust exacerbates allergic diseases, how it affects the onset of autoimmune diseases is unclear. No epidemiological investigations or animal experiments have been conducted so far to elucidate the effects of desert dust on autoimmune diseases. Here, we focused on particulate matter, such Asian sand dust (ASD) that has been known to cause adverse health effects in East Asian countries, and conducted animal experiments to examine how ASD influences type 1 diabetes (T1D), an autoimmune disease. An ASD ...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
Applied Physiology, Nutrition, and Metabolism, e-First Articles. We are currently facing an “obesity epidemic” worldwide. Promoting inefficient metabolism in muscle represents a potential treatment for obesity and its complications. Sarco(endo)plasmic reticulum (SR) Ca2+-ATPase (SERCA) pumps in muscle are responsible for maintaining low cytosolic Ca2+ concentration through the ATP-depe ndent pumping of Ca2+ from the cytosol into the SR lumen. SERCA activity has the potential to be a critical regulator of body mass and adiposity given that it is estimated to contribute upwards of 20% of daily energy expenditure....
Source: Applied Physiology, Nutrition, and Metabolism - Category: Physiology Authors: Source Type: research
Conclusions: Findings suggests that dual users of alcohol and marijuana with negative affect symptoms engage in substance use for similar reasons as single substance users with negative affect symptoms. Intervention efforts should examine ways to replace substance-related coping and expansion methods with non-substance-related methods. PMID: 31818171 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
More News: Alcoholism | Anesthesia | Anesthesiology | Ataxia | Brain | Dementia | Depression | Diabetes | Eating Disorders & Weight Management | Endocrinology | Genetics | Geriatrics | Hypertension | Hypothyroidism | Men | Neurology | Neurosurgery | Obesity | Psychiatry | Sleep Apnea | Sleep Disorders | Sleep Medicine | Women