Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction

In patients with coronary disease and preserved ejection fraction, T2DM results in impaired relaxation and increased fibrosis of the right atrium, with preserved myocardial contractile function. The novel finding of increased expression of SERCA2a:phospholamban ratio suggests a compensatory mechanism to enhance relaxation and maintain diastolic function of the fibrotic atrial myocardium.
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Source Type: research