Doctors Perform 1st U.S. Living-Donor Uterine Transplant

Infertility procedure was tried in 4 women but has remained successful in only one, Texas team says Source: HealthDay Related MedlinePlus Page: Organ Transplantation
Source: MedlinePlus Health News - Category: Consumer Health News Source Type: news

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Gonadal impairment represents an important late effect occurring after hematopoietic stem cell transplantation (HSCT), affecting the quality of life of young transplanted patients. The proportion and severity of gonadal late impairment depends on type and cumulative dosage of gonadotoxic chemotherapeutic agents, type of HSCT, age at HSCT, additional use of Total Body Irradiation (TBI) for conditioning or radiotherapy (cranial and pelvic radiotherapy) administered before HSCT [1]. Gonadal complications are recognized as a consequence of myeloablative conditioning regimens, in particular based on TBI or Busulfan (Bu), and in...
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
(Abstracted from Lancet 2018;392:2697–2704) Infertility is common and affects about 10% to 15% of couples. In such couples, 1 in 500 women has infertility due to uterine causes, with uterine agenesis (Mayer-Rokitansky-Küster-Hauser [MRKH] syndrome), or due to hysterectomy, malformation, or the sequelae of infection or surgery.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: OBSTETRICS: ETHICS, MEDICOLEGAL ISSUES, AND PUBLIC POLICY Source Type: research
Conclusions In both mouse and human, uNK cells are the most prominent immune cells that occupy the maternal-fetal interface. The uNK cells appear to engage and establish complex interactions with the surrounding tissue, which impact their function. As more cell subsets are identified within the heterogeneous uNK cell population, it is anticipated that their functional heterogeneity will extend beyond vascular modification, growth-promotion and memory generation. Author Contributions DS wrote the manuscript. LY provided the micrographs and WY edited the manuscript. Funding Work in the Yokoyama lab on uterine NK cells i...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions and Perspectives It is interesting that watershed events, such as the loss of Neu5Gc from the glycocalyx of human cells have occurred numerous times in many mammalian and other vertebrate species. These cases of convergent evolution represent precious opportunities for increased understanding of evolutionary processes. In some respects, Neu5Gc is an ideal self-molecule as it is “private” to vertebrates and, based on current data, has yet to be successfully mimicked by microbes. Against the background of this benefit, the loss of Neu5Gc appears paradoxical and may implicate strong selective regimes,...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study was designed to examine the relationship between the stress level as inferred from the amount of the enzyme alpha-amylase secreted in saliva (SAA) and pregnancy outcome in infertile couples undergoing in vitro fertilization and embryo transplantation (IVF-ET). A prospective cohort study was conducted in the Reproductive Medicine Centre of Zhengzhou University Hospital in Henan, China. Four hundred fifty-seven infertile couples undergoing in vitro fertilization and embryo transplantation (IVF-ET) for the first time participated in the study. Couples collected saliva samples the morning before the start of their f...
Source: Stress - Category: Research Tags: Stress Source Type: research
Uterine factor infertility (UFI) may affect up to 1 in 500 reproductive age women. The uterus is an essential component of achieving pregnancy and carrying a pregnancy to term successfully. There are many etiologies of UFI which may be categorized into either congenital or acquired causes. In this review, we discuss the different causes of UFI as well as the treatment options, which now includes uterine transplant.
Source: Clinical Obstetrics and Gynecology - Category: OBGYN Tags: An Update in REI and ART Source Type: research
Publication date: May–June 2019Source: Journal of Minimally Invasive Gynecology, Volume 26, Issue 4Author(s): Shailesh Puntambekar, Seema Puntambekar, Milind Telang, Pankaj Kulkarni, Shardul Date, Mangesh Panse, Ravindra Sathe, Nikhil Agarkhedkar, Neeta Warty, Sandesh Kade, Manoj Manchekar, Mihir Chitale, Hirav Parekh, Kajal Parikh, Mehul Mehta, Bhushan Kinholkar, Joy Shankar Jana, Avinash Pare, Shailendra Kanade, Abhay SadreAbstractStudy ObjectiveTo evaluate 2 cases of uterine transplant surgery that used utero-ovarian veins as outflow channels, internal iliac arteries for perfusion, and the organ harvest surgery pe...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Conclusions In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases. Author Contributions All authors listed have made a substantial, direct and i...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conservation of chicken male germ line by orthotopic transplantation of primordial germ cells from genetically distant donors†. Biol Reprod. 2019 Apr 13;: Authors: Mucksová J, Reinišová M, Kalina J, Lejčková B, Hejnar J, Trefil P Abstract Successful derivation and cultivation of primordial germ cells (PGC) opened the way to efficient transgenesis and genome editing in the chicken. Furthermore, implantation of male PGCs from non-chicken galliform species into the chicken embryos resulted in cross-species germ line chimeras and viable offspring. We have recently impro...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
ConclusionsWe developed a novelex vivo sheep uterus model for prolonged perfusion. This model proved to be able to distinguish reperfusion injury ‐related differences associated to organ preservation. The experimental setup is a platform that can be used to conduct further studies on uterine ischemia‐ and reperfusion injury that may lead to improved human uterus transplantation protocols.This article is protected by copyright. All rights reserved.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: Original Research Article Source Type: research
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