Doctors Perform 1st U.S. Living-Donor Uterine Transplant

Infertility procedure was tried in 4 women but has remained successful in only one, Texas team says Source: HealthDay Related MedlinePlus Page: Organ Transplantation
Source: MedlinePlus Health News - Category: Consumer Health News Source Type: news

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Abstract Mechanistic target of rapamycin (mTOR) controls cell growth and metabolism in response to environmental and metabolic signals. Rapamycin robustly extends the lifespan in mammals and has clinical relevance in organ transplantation and cancer therapy but side effects include male infertility. Here, we report that chronic rapamycin treatment causes spermatogenic arrest in adult male mice due to defects in sex body formation and meiotic sex chromosome inactivation (MSCI). Many sex chromosome-linked genes were up-regulated in isolated pachytene spermatocytes from rapamycin-treated mice. RNA-Seq analysis also i...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
Doctors at the University of Gothenburg in Sweden have revealed the first woman has become pregnant in a trial using a robot to perform womb transplant surgery for infertile women.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
On an afternoon in November, a couple hosted a birthday party for their 1-year-old son. As family and friends gathered around the child to sing “Happy Birthday,” his parents addressed a milestone that reached well beyond the room. “It was emotional,” recalls the mother. “It took a lot more than a nine-month pregnancy to get him, and we wouldn’t be where we are without everyone’s support.” Many parents will tell you their child is miraculous. But the mere existence of this particular boy, who just a month earlier had taken his first steps, brings the miracle somehow closer to ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized fertility Research Source Type: news
When Noah Shulman was born a few days after Christmas 2016, his parents Kristelle and Evan had no reason to worry about him. The pregnancy went smoothly, and so did the birth. But within a few days of taking his first breath, Noah began to struggle. He wasn’t feeding, so he started losing weight. He was also lethargic. Several pediatricians reassured the Shulmans that they were probably just overly sensitive to Noah’s symptoms because Kristelle is a nurse and Evan is a physician assistant–a case of first-time-parent-white-coat syndrome. “They kind of dismissed us as neurotic parents,” says Eva...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized fertility Research Source Type: news
Abstract In both women and men, chronic kidney disease (CKD) is associated with decreased fertility. Though a multitude of factors contribute to the reduction in fertility in this population, progressively impaired function of the hypothalamic-pituitary-gonadal axis appears to play a key role in the pathophysiology. There is limited research on strategies to manage infertility in the CKD population, but intensive hemodialysis, kidney transplantation, medication management and assisted reproductive technologies (ART) have all been proposed. Though fertility and reproductive care are reported as important elements o...
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research
Publication date: Available online 29 December 2018Source: Journal of Minimally Invasive GynecologyAuthor(s): Shailesh Puntambekar, Seema Puntambekar, Milind Telang, Pankaj Kulkarni, Shardul Date, Mangesh Panse, Ravindra Sathe, Nikhil Agarkhedkar, Neeta Warty, Sandesh Kade, Manoj Manchekar, Mihir Chitale, Hirav Parekh, Kajal Parikh, Mehul Mehta, Bhushan Kinholkar, Joy Shankar Jana, Avinash Pare, Shailendra Kanade, Abhay SadreABSTRACTStudy objectiveTo evaluate 2 cases of uterine transplant surgery that used utero-ovarian veins as outflow channels, internal iliac arteries for perfusion, and the organ harvest surgery being pe...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Publication date: Available online 21 December 2018Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Mats Brännström, Pernilla Dahm-KählerAbstractAbsolute uterine factor infertility (AUFI), with uterine absence or presence of a non-functional uterus, was considered untreatable until 2014, when the first child was born after transplantation of a uterus from a postmenopausal woman to a woman of fertile age who was born with no uterus, as part of the MRKH syndrome. Concerning gynaecological cancer, AUFI may occur after hysterectomy for malignancy or after surgery/radiation that ...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
This study sought to evaluate perceptions and insights regarding uterine transplantation among members of a women's health care national specialty organization in Canada. METHODS: The investigators obtained permission and used an electronic survey developed by Bortoletto et al. to conduct a cross-sectional study of members of the SOGC between April and May 2018. Participants were requested to answer a total of 29 questions grouped into four different categories: personal opinions and attitudes, medical opinions, ethical opinions, and demographics. The investigators compared answers with a published survey of members of...
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
We describe, to our knowledge, the first case worldwide of livebirth following uterine transplantation from a deceased donor in a patient with MRKH syndrome. The results establish proof-of-concept for treating uterine infertility by transplantation from a deceased donor, opening a path to healthy pregnancy for all women with uterine factor infertility, without need of living donors or live donor surgery.FundingFundação de Amparo à Pesquisa do Estado de São Paulo and Hospital das Clínicas, University of São Paulo, Brazil.
Source: The Lancet - Category: General Medicine Source Type: research
A novel transplantation procedure may help more infertile women become pregnant.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Uterus Transplants Pregnancy and Childbirth Infertility Lancet, The (Journal) Brazil Source Type: news
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