Gelatin-based membrane containing usnic acid-loaded liposome improves dermal burn healing in a porcine model

Publication date: 20 November 2016 Source:International Journal of Pharmaceutics, Volume 513, Issues 1–2 Author(s): Paula Santos Nunes, Alessandra Silva Rabelo, Jamille Cristina Campos de Souza, Bruno Vasconcelos Santana, Thailson Monteiro Menezes da Silva, Mairim Russo Serafini, Paula dos Passos Menezes, Bruno dos Santos Lima, Juliana Cordeiro Cardoso, Júlio César Santana Alves, Luiza Abrahão Frank, Sílvia Stanisçuaski Guterres, Adriana Raffin Pohlmann, Malone Santos Pinheiro, Ricardo Luiz Cavalcanti de Albuquerque, Adriano Antunes de Souza Araújo There are a range of products available which claim to accelerate the healing of burns; these include topical agents, interactive dressings and biomembranes. The aim of this study was to assess the effect of a gelatin-based membrane containing usnic acid/liposomes on the healing of burns in comparison to silver sulfadiazine ointment and duoDerme® dressing, as well as examining its quantification by high performance liquid chromatography. The quantification of the usnic acid/liposomes was examined using high performance liquid chromatography (HPLC) by performing separate in vitro studies of the efficiency of the biomembranes in terms of encapsulation, drug release and transdermal absorption. Then, second-degree 5cm2 burn wounds were created on the dorsum of nine male pigs, assigned into three groups (n=3): SDZ – animals treated with silver sulfadiazine ointment; GDU – animals treated with duoDerme®; U...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research