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Cognitive Impairment, Depression Affect Oral Cancer Therapy Adherence

Patients with working memory dysfunctions and depression may be more likely to be nonadherent to oral cancer therapies, according to the results of a study presented at ESMO.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Tags: News Source Type: news

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Publication date: Available online 22 April 2018 Source:EXPLORE Author(s): Eran Ben-Arye, Ilana Doweck, Elad Schiff, Noah Samuels Context Chemotherapy-induced taste disorder (CITD) is a common adverse effect among patients with cancer, with no effective known treatment. Objectives Exploring the impact of a patient-tailored complementary and integrative medicine (CIM) treatment program on CITD-related severity. Design Prospective study on patients’ chart. Setting Integrative oncology program operating within the Clalit Healthcare Oncology Service in northern Israel. Patients Patients were referred by their oncology h...
Source: EXPLORE: The Journal of Science and Healing - Category: Complementary Medicine Source Type: research
This article reviews the clinical questions and bottom-line answers from these studies. Blood pressure should be measured after a period of rest, using a bare arm, and orthostatic blood pressure is more predictive when measured after one minute of standing rather than three minutes. Intensive blood pressure lowering results in cardiovascular benefits but also renal harms in high-risk patients with an average age of 68 years. The initiation of a statin for primary prevention does not reduce cardiovascular events in adults 65 years or older. Sterile gloves do not reduce the risk of infection for common outpatient skin proced...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
This study demonstrates that small peptide domains derived from native protein amelogenin can be utilized to construct a mineral layer on damaged human enamel in vitro. Six groups were prepared to carry out remineralization on artificially created lesions on enamel: (1) no treatment, (2) Ca2+ and PO43- only, (3) 1100 ppm fluoride (F), (4) 20 000 ppm F, (5) 1100 ppm F and peptide, and (6) peptide alone. While the 1100 ppm F sample (indicative of common F content of toothpaste for homecare) did not deliver F to the thinly deposited mineral layer, high F test sample (indicative of clinical varnish treatment) formed mainly C...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion: The study observed that there was marked dysregulation of both morning plasma and salivary cortisol levels along with higher scores of anxiety and depression in OSCC.
Source: Journal of Oral and Maxillofacial Pathology - Category: ENT & OMF Authors: Source Type: research
Abstract Diacylglycerol lipase alpha (DAGLA), which catalyzes the hydrolysis of diacylglycerol to 2-arachidonoylglycerol and free fatty acid, is required for axonal growth during the brain development and for retrograde synaptic signaling at mature synapses. So far, no information was found regarding the possible role of DAGLA in human tumorigenesis. Thus, the current study sought to clarify the contribution of DAGLA in oral squamous cell carcinomas (OSCCs) and assess the clinical possibilities for OSCC treatment. Using real-time quantitative reverse transcription-polymerase chain reaction, immunoblotting, and imm...
Source: Experimental Cell Research - Category: Cytology Authors: Tags: Exp Cell Res Source Type: research
As the patient talked, I found myself nodding my head. In so many ways, she was just like me. Highly educated, a professional, a woman who had worked hard and long to get where she was. And then cancer took it all away, or at least that’s the way she described it. She was diagnosed with metastatic cancer one year ago and finally had time to take a breath after the rigors of surgery, radiation, endocrine manipulation therapy, and chemotherapy. Nothing seems to have gone right for her; she was hospitalized with febrile neutropenia twice during the months of chemotherapy, she has osteoporosis and has had to stop the win...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Source Type: blogs
ConclusionsThe oral exposure of PPI was enhanced in MN rats, which suggested that nutritional status alters the absorption of PPI, and thus the dosage of PPI should be modified during the treatment of cancer patient with PCM.
Source: European Journal of Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research
ConclusionsPatient‐specific characteristics (older age, prior history of mental health comorbidities and use of non‐opioid analgesics) and prescriber choice of initial opioid (transdermal formulation and higher total OMEs) were found to strongly predict persistent use. This information may help prescribers target monitoring and early intervention efforts in order to prevent harms associated with the long‐term use of opioids.
Source: British Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL ARTICLE Source Type: research
The objective of the current study was to assess the preoperative and postoperative oral cancer pain, anxiety, and quality of life of OSCC patients with invasive treatment procedure.MethodsThe current study was conducted by interviewing 21 (10 males; 11 females) patients who had been diagnosed with stage 3 and stage 4 OSCC and about to go through surgery at the inpatient ward of Surgical Oncology Department, Hasan Sadikin Hospital, Bandung, Indonesia. A preoperative and interview was conducted by using the Hospital Anxiety and Depression Scale (HADS), the European Organization for Research and Treatment of Cancer Quality o...
Source: Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: Available online 3 January 2018 Source:British Journal of Oral and Maxillofacial Surgery Author(s): R.J. Wotherspoon, A.N. Kanatas, S.N. Rogers HaNDLE-on-QoL (Head And Neck Database Listing Evidence on QoL) is a searchable database that comprises abstracts of papers that have used questionnaires to report on quality of life (QoL) in patients with cancer of the head and neck. It can be searched by title, first author, year of publication, words used in the abstract, site of cancer, study design, and questionnaires used. The aim of this paper was to summarise its contents. In May 2017 we searched the websi...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
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