Cognitive Impairment, Depression Affect Oral Cancer Therapy Adherence

Patients with working memory dysfunctions and depression may be more likely to be nonadherent to oral cancer therapies, according to the results of a study presented at ESMO.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Tags: News Source Type: news

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ConclusionsHigh quality systematic reviews and meta-analyses are very crucial to understanding the relationship between systemic and periodontal disease. It is critical for medical practitioners to be able to inform patients of oral health and specific periodontal health concerns.
Source: Journal of Evidence Based Dental Practice - Category: Dentistry Source Type: research
ConclusionsPanoramic radiographs can demonstrate that any localized marked anatomic depression in the mandible could mimic a cystic lesion and, in some cases, more aggressive pathosis. It is important to recognize the specific radiographic features and the location of the morphologic variants of the mandible and utilize other available imaging studies before making any interpretation and/or initiating unnecessary invasive diagnostic procedures.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
CONCLUSIONS: MiR-21 could participate in the proliferation of cultured SCC-15 cells via targeting TNF-α expression, but without any significant effects on cell apoptosis. PMID: 30536317 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
ConclusionThe determinants of non-adherence and non-persistence are multi-dimensional and influenced by several factors. The three categories of adherence barriers should be evaluated and considered when designing future interventions to enhance OET adherence for a tailored approach.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Abstract Crohn's disease is a chronic inflammatory condition that affects the gastrointestinal tract. It can cause lesions from mouth to anus and may result in extraintestinal complications. The prevalence of Crohn's disease is increasing in adults and children. Genetic predispositions to Crohn's disease have been identified, and specific environmental factors have been associated with its development. Common presenting symptoms include diarrhea, abdominal pain, rectal bleeding, fever, weight loss, and fatigue. Physical examination should identify unstable patients requiring immediate care, include an anorectal ex...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
Authors: Badria FA, Suliman SN, Elsbaey M, El-Naggar MH Abstract Iron overload is implicated in many disorders in the body such as heart failure, liver cirrhosis and fibrosis, gallbladder disorders, diabetes, arthritis, depression, infertility, and cancer. Even though synthetic chelating agents are available, they have several limitations such as poor oral bioavailability, short plasma half-life, high cost and numerous side effects. Therefore, the aim of this study is using agricultural residues as sources for alternative efficient, benign, and economic iron chelators of natural origin. Eighteen agricultural residu...
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
The majority of patients with acute myeloid leukemia (AML), including nearly all patients older than age 60, present with multiple, sequentially acquired, somatic mutations. The 5-year overall survival (OS) for AML patients ≥ 60 with the current standard-of-care is less than 10 percent and the median OS in most genetically defined subtypes is
Source: Blood - Category: Hematology Authors: Tags: 615. Acute Myeloid Leukemia: Commercially Available Therapy, excluding Transplantation: Targeted Therapy For Adults Diagnosed With Acute Myeloid Leukemia Source Type: research
Conclusion: Response to acalabrutinib remained consistent during long-term (>24-month) follow-up, including high response rates, median PFS of 19.5 months, and a median OS that has not yet been reached, confirming efficacy in patients with relapsed/refractory MCL. The AE profile was largely similar to earlier reporting, with limited additional safety events observed with an additional year of follow-up.DisclosuresWang: Celgene: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Dava Oncology: Honoraria; AstraZeneca: Consultancy, Research Funding; Pharmacyclics: Honoraria, R...
Source: Blood - Category: Hematology Authors: Tags: 623. Mantle Cell, Follicular, and Other Indolent B-Cell Lymphoma-Clinical Studies: Poster II Source Type: research
This study's researchers approached all people turning 85 in 2006 in two cities in the UK for participation. At the beginning of the study in 2006-2007, there were 722 participants, 60 percent of whom were women. The participants provided researchers with information about what they ate every day, their body weight and height measurements, their overall health assessment (including any level of disability), and their medical records. The researchers learned that more than one-quarter (28 percent) of very old adults had protein intakes below the recommended dietary allowance. The researchers noted that older adults w...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 7 November 2018Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): K. Kumar, S. Kumar, D. Mehrotra, S.C. Tiwari, V. Kumar, S. Khandpur, R.C. DwivediAbstractThe high morbidity and mortality that is associated with oral cancer places a huge psychological burden on patients. The purpose of this prospective study was to evaluate levels of depression, anxiety, and stress, at three time points using DASS-21 (Depression, Anxiety and Stress Scale-21). We also compared DASS-21 with HADS (Hospital Anxiety and Depression Scale). A total of 111 patients were enrolled and 75 of them co...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
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