Novel role of Vav1-Rac1 pathway in actin cytoskeleton regulation in Interleukin-13-induced minimal change-like nephropathy

In conclusion, we have demonstrated the role of Vav1-Rac1 pathway characterised by phosphorylation of Vav1, activation of Rac1 and the subsequent actin cytoskeleton rearrangement in IL-13 induced podocyte injury, possibly explaining the podocyte foot process effacement seen in our IL-13 overexpression rat model.

Source: Clinical Science - October 4, 2016 Category: Biomedical Science Authors: Chan, C.-Y., Ng, K.-H., Chen, J., Lu, J., Lee, C. G.-L., Tan, P.-H., Jordan, S. C., Yang, H. H., Yap, H.-K. Tags: PublishAheadOfPrint Source Type: research