Cervical HPV infection in Romanian women infected with HIV during early childhood

Human papillomavirus (HPV) is the most common cause of cervical cancer worldwide, and Romania has the highest rate of cervical cancer in Europe. Sixty-five young Romanian women infected with HIV during early childhood and 25 control subjects were evaluated for the presence of cervical HPV infection and for cytologic abnormalities. HPV infection was evaluated longitudinally in 42 HIV-infected individuals. Overall 28/65 (43.1%) of HIV-infected and 8/25 (32.0%) of uninfected subjects were infected with HPV, and 21/65 (32.3%) and 6/25 (24%) had high-risk subtypes, respectively. In HIV-infected women, those maintaining or acquiring a new subtype in follow-up were more likely to have a lower nadir (p = 0.04) and current (p = 0.01) CD4 cell counts. The incidence rate for HPV acquisition events was 0.69 per subject per year, and 0.52 for high-risk subtypes. In the HIV-infected group, 9/13 (69.2%) individuals with abnormal cytology progressed at follow-up. Although HPV prevalence was similar to controls, the rate of Pap smear abnormalities was much higher, possibly due to the decreased ability to mount new immune responses. Given the high rate of incident detection of vaccine preventable strains and cytologic progression in this cohort, HPV vaccination may be beneficial at any age in co-infected women.
Source: International Journal of STD and AIDS - Category: Global & Universal Authors: Tags: Original research articles Source Type: research

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Source: Revista Brasileira de Saude Materno Infantil - Category: Midwifery Source Type: research
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Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
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Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
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Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
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Source: University of Rochester Medical Center Press Releases - Category: Universities & Medical Training Authors: Source Type: news
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