1st U.S. Living-Donor Uterine Transplant Performed

Infertility procedure was tried in 4 women but has remained successful in only one, Texas team says
Source: WebMD Health - Category: Consumer Health News Source Type: news

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ConclusionsEvidence does not yet support clinical application of SSCs in humans. However, significant progress in the in vitro and in vivo development of SSCs, including differentiation into functional germ cells, gives reason for cautious optimism for future research.
Source: Arab Journal of Urology - Category: Urology & Nephrology Source Type: research
Conditions:   Absolute Uterine Factor Infertility;   Transplantation;   Mrk Anomaly Intervention:   Procedure: uterus transplantation Sponsor:   Sahlgrenska University Hospital, Sweden Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsEvidence does not yet support clinical application of SSCs in humans. However, significant progress in the in vitro and in vivo development of SSCs, including differentiation into functional germ cells, gives reason for cautious optimism for future research.
Source: Arab Journal of Urology - Category: Urology & Nephrology Source Type: research
A synthetic organ – made out of the woman's own tissue – could be transplanted into a female left infertile due to medical treatment. She could then go on to produce eggs naturally.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
To regenerate functional endometrium tissue using “cell sheet” techniques as a regenerative medicine approach to address endometrial disorders causing female factor infertility.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Original article Source Type: research
CONCLUSIONS: Successful kidney transplantation leads to the normalization of serum concentrations of hormones linked to fertility disorders in women with chronic kidney disease. . PMID: 29952423 [PubMed - in process]
Source: Endokrynologia Polska - Category: Endocrinology Authors: Tags: Endokrynol Pol Source Type: research
Abstract Severe uterine damage and infection lead to intrauterine adhesions, which result in hypomenorrhea, amenorrhea and infertility. Cell sheet engineering has shown great promise in clinical applications. Adipose-derived stem cells (ADSCs) are emerging as an alternative source of stem cells for cell-based therapies. In the present study, we investigated the feasibility of applying ADSCs as seed cells to form scaffold-free cell sheet. Data showed that ADSC sheets expressed higher levels of FGF, Col I, TGFβ and VEGF than ADSCs in suspension, while increased expression of this gene set was associated with st...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
Conclusions Laparoscopic-assisted uterus donor retrieval is feasible and affords all the advantages of a minimally invasive technique, thereby reducing the morbidity of the procedure. It helps in better dissection of the vessels, shortens the operative time, and helps to minimize tissue handling of the harvested uterus and vessels.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Purpose of review The purpose of this review is to analyze what is known to date about the relation between telomeres and male fertility, and if it is possible for telomeres, or elements related to them, to be used as new prognostic biomarkers in fertility treatment. Recent findings Cells in germ series, including spermatozoids, have longer telomeres (10–20 kb), and do not seem to undergo the shortening that takes place in somatic cells with age as they present telomerase activity. Longer telomere length found in the sperm of older fathers, influences their offspring possessing cells with longer telomere length....
Source: Current Opinion in Obstetrics and Gynecology - Category: OBGYN Tags: FERTILITY, IVF AND REPRODUCTIVE GENETICS: Edited by Emre Seli and Juan A. GarcĂ­a-Velasco Source Type: research
(Abstracted from Human Reprod 2018;33:212–219) Ten percent to 20% of all ovarian epithelial tumors are borderline ovarian tumors (BOTs). These low-grade malignancies rarely metastasize.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: Gynecology: Infertility/Reproductive Technologies Source Type: research
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