Gene found that raises risk of childhood ear infections

(Children's Hospital of Philadelphia) Researchers have discovered a gene region that raises the risk a child will have a middle ear infection, known to doctors as acute otitis media -- and known to parents as one reason for a screaming, unhappy preschooler. The finding may offer an early clue to helping doctors develop more effective treatments to prevent one of the most common childhood illnesses.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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ConclusionsVEGF and its receptors function to induce the production of middle-ear effusions (MEEs) at acute stage of OME rather than chronic or recurrent stage, which is mainly mediated by HIF-1 α pathway. The formation of mucoid effusions is associated with MUC5B and VEGFR2, but not with duration and recurrence of OME.
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
Acute bacterial otitis media is usually caused by otopathogens ascending to the middle ear from the nasopharynx (NP). However, it is unknown if the nasopharyngeal microbiota of children with acute otitis media (AOM) can serve as an age-dependent or independent proxy for the microbial communities of the middle ear fluid (MEF) as there is a lack of 16S rRNA amplicon sequencing studies simultaneously analyzing the microbial communities of the two sites. Within this study, we performed 16S rRNA next generation sequencing on a total of 286 nasopharyngeal swabs (NPS) collected between 2004 and 2013 within a Swiss national AOM ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
​BY ADRIANA PORTO, MD; KELLY LEVASSEUR, DO; &SHANNA JONES, MDA 7-year-old girl presented to the emergency department with intermittent low-grade fever over the previous six days. She also had a sore throat, cough, and nasal congestion. Her mother reported a fever of 105°F with vomiting, cough, and congestion on the day of her presentation. She also noted that the patient complained of right leg pain and refused to walk or bear weight on her right leg, which was new the day of presentation. The patient pointed to the back of her right calf when asked where the pain was located. Her mother said the patient did not ...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
To validate and evaluate the reliability of the Dutch version of the Chronic Ear Survey (CES) in patients suffering from Chronic Suppurative Otitis Media (CSOM) and to evaluate clinical outcomes of surgery usi...
Source: Health and Quality of Life Outcomes - Category: International Medicine & Public Health Authors: Tags: Research Source Type: research
AbstractTo evaluate hearing results following canal wall down mastoidectomy with ossicular reconstruction for Chronic Suppurative Otitis Media of Active Squamosal variety&evaluate various factors related to surgery impacting hearing results. This prospective study involves 40 patients of active squamosal variety of chronic otitis media who attended ENT OPD and underwent canal wall down mastoidectomy with ossiculoplasty during the period from November 2014 to October 2015. All the patients were subjected to pre and 3  months post-op hearing assessment. Based on the hearing outcome, we expressed our study results in...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - Category: ENT & OMF Source Type: research
Publication date: Available online 13 June 2019Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): F. Carré, S. Achard, I. Rouillon, M. Parodi, N. LoundonAbstractThe goal is to clarify the epidemiology of hearing loss in patients with osteogenesis imperfecta (OI), so as to improve management. A literature review analyzed data from 15 patient series. Hearing loss prevalence in OI varied widely, from 2% to 94.1%. Typically, hearing loss was conductive in young patients and sensorineural in older patients. Prevalence increased with age, but after 50 years the increase was slight, and seldom...
Source: European Annals of Otorhinolaryngology, Head and Neck Diseases - Category: ENT & OMF Source Type: research
Conclusion: While the exact role of intratympanic injections requires additional trials, triamcinolone resulted in similar outcomes compared to studies using dexamethasone or methylprednisolone. Due to favorable pharmacological properties, triamcinolone represents a safe and efficacious alternative for intratympanic treatment in idiopathic sensorineural hearing loss.
Source: Otology and Neurotology - Category: ENT & OMF Tags: SENSORINEURAL HEARING LOSS AND TINNITUS Source Type: research
Conclusions: Data from the current study suggest that canalplasty offers benefit regarding closure rate in medial graft tympanoplasty. Use of cartilage also portended a higher rate of perforation closure. Canalplasty should be considered when using medial graft techniques if exposure is limited due to bony canal anatomy.
Source: Otology and Neurotology - Category: ENT & OMF Tags: MIDDLE EAR AND MASTOID DISEASE Source Type: research
Conclusion: Neglected mastoid cavity care, low socioeconomic status, poor personal hygiene, homelessness, and chronic suppurative otitis media are likely contributing factors to this uncommon presentation occurring in an urban setting.
Source: Otology and Neurotology - Category: ENT & OMF Tags: MIDDLE EAR AND MASTOID DISEASE Source Type: research
No abstract available
Source: Otology and Neurotology - Category: ENT & OMF Tags: LETTERS TO THE EDITOR Source Type: research
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