White Matter Changes May Precede Gray Matter Loss in Elderly with Subjective Memory Impairment

Conclusion: SMI subjects with a high risk of progression had more WM microstructural disruption than those with a low risk, and the changes were not explained by GM atrophy. Our findings suggest that the degree of microstructural alterations in SMI may be distinctive according to the risk factors and may precede GM atrophy.Dement Geriatr Cogn Disord 2016;42:227-235
Source: Dementia and Geriatric Cognitive Disorders - Category: Geriatrics Source Type: research