Coronavirus and neurological disease: Direct link

For the first time, researchers have found proof of a direct association between strain OC 43 of the human coronavirus (HCoV) and neurological disease in humans. Researchers suggest the neuropathological effects of this virus are responsible for approximately 20% of common colds and more severe respiratory conditions in certain vulnerable individuals.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Abstract The four endemic human coronaviruses HCoV-229E, -NL63, -OC43, and -HKU1 contribute a considerable share of upper and lower respiratory tract infections in adults and children. While their clinical representation resembles that of many other agents of the common cold, their evolutionary histories, and host associations could provide important insights into the natural history of past human pandemics. For two of these viruses, we have strong evidence suggesting an origin in major livestock species while primordial associations for all four viruses may have existed with bats and rodents. HCoV-NL63 and -229E ...
Source: Adv Data - Category: Epidemiology Authors: Tags: Adv Virus Res Source Type: research
Your nose is dripping like a leaky faucet, your throat is sore and you can’t stop sneezing. You don’t have a fever, but you feel wiped out—like you could curl up on the floor and fall asleep. Do you have a cold or the flu? If you guessed cold, you’re probably right. But experts say that differentiating the common cold (an upper respiratory infection) from the flu (influenza) can be trickier than most people assume. “There is huge overlap among non-influenza viruses and the symptoms produced by influenza and other bugs,” says Dr. Bruce Barrett, a professor of family medicine and community...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized public health Source Type: news
Community acquired respiratory viruses (CARV) are an important cause of morbidity and mortality among Hematopoietic Stem Cell Transplant recipients (HSCT). Reported incidence of CARV in HSCT varies from 4% on early days of antigen testing to ∼40% using PCR based detection. Most commonly detected viruses are Rhinovirus/enterovirus (22-34%), followed by Influenza, Respiratory Syncytial Virus (RSV) and Parainfluenza on similar range. Less frequently, with important morbidity associated are Coronavirus (3-11%), Adenovirus and Human metapn eumovirus (HMPV).
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Type: Invited Presentation Source Type: research
Publication date: 2018Source: Advances in Virus Research, Volume 100Author(s): Victor M. Corman, Doreen Muth, Daniela Niemeyer, Christian DrostenAbstractThe four endemic human coronaviruses HCoV-229E, -NL63, -OC43, and -HKU1 contribute a considerable share of upper and lower respiratory tract infections in adults and children. While their clinical representation resembles that of many other agents of the common cold, their evolutionary histories, and host associations could provide important insights into the natural history of past human pandemics. For two of these viruses, we have strong evidence suggesting an origin in ...
Source: Advances in Virus Research - Category: Virology Source Type: research
The objective of this study was to test the relevance of such a model for the discovery and validation of antiviral drugs. Fully differentiated 3D nasal epithelium cultures were inoculated with picornaviruses, a coronavirus and influenza A viruses in the absence or in the presence of reference antiviral drugs. Results showed that, rupintrivir efficiently inhibits the replication of respiratory picornaviruses in a dose dependent manner and prevents the impairment of the mucociliary clearance. Similarly, oseltamivir reduced the replication of influenza A viruses in a dose dependent manner and prevented the impairment of the ...
Source: Antiviral Therapy - Category: Virology Source Type: research
Publication date: 2018Source: Advances in Virus Research, Volume 100Author(s): Victor M. Corman, Doreen Muth, Daniela Niemeyer, Christian DrostenAbstractThe four endemic human coronaviruses HCoV-229E, -NL63, -OC43, and -HKU1 contribute a considerable share of upper and lower respiratory tract infections in adults and children. While their clinical representation resembles that of many other agents of the common cold, their evolutionary histories, and host associations could provide important insights into the natural history of past human pandemics. For two of these viruses, we have strong evidence suggesting an origin in ...
Source: Advances in Virus Research - Category: Virology Source Type: research
The objective of this study was to test the relevance of such a model for the discovery and validation of antiviral drugs. Fully differentiated 3D nasal epithelium cultures were inoculated with picornaviruses, a coronavirus and influenza A viruses in the absence or in the presence of reference antiviral drugs. Results showed that, rupintrivir efficiently inhibits the replication of respiratory picornaviruses in a dose dependent manner and prevents the impairment of the mucociliary clearance. Similarly, oseltamivir reduced the replication of influenza A viruses in a dose dependent manner and prevented the impairment of the ...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
(Natural News) People are more vulnerable to getting sick when seasons change, especially during spring and fall, and experts may now know why. According to research, it’s not the cold air that makes people sick; rather, it’s the virus. Rhinoviruses and coronaviruses, the two main causes of the common cold, can multiply quickly when the...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
AbstractHuman coronavirus OC43 (HCoV-OC43) is a respiratory virus that usually causes a common cold. However, it has the potential to cause severe infection in young children and immunocompromised adults. Both SARS-CoV and MERS-CoV were shown to express proteins with the potential to evade early innate immune responses. However, the ability of HCoV-OC43 to antagonise the intracellular antiviral defences has not yet been investigated. The potential role of the HCoV-OC43 structural (M and N) and accessory proteins (ns2a and ns5a) in the alteration of antiviral gene expression was investigated in this study. HCoV-OC43M, N, ns...
Source: Archives of Virology - Category: Virology Source Type: research
Publication date: June 2018 Source:Biochimica et Biophysica Acta (BBA) - Biomembranes, Volume 1860, Issue 6 Author(s): Wahyu Surya, Yan Li, Jaume Torres Coronaviruses (CoV) cause common colds in humans, but are also responsible for the recent Severe Acute, and Middle East, respiratory syndromes (SARS and MERS, respectively). A promising approach for prevention are live attenuated vaccines (LAVs), some of which target the envelope (E) protein, which is a small membrane protein that forms ion channels. Unfortunately, detailed structural information is still limited for SARS-CoV E, and non-existent for other CoV E proteins. ...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
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