Patient-first technology: Improving care for the chronically ill

Prevention is one of the most important aspects of health care, but what about those patients who already have serious chronic illnesses that do not have a cure? Harvey Fineberg, MD, president of the  Gordon and Betty Moore Foundation, spoke last week at Health 2.0 in Silicon Valley reminding entrepreneurs that we need to develop solutions for patients with chronic illnesses to live happier, more comfortable lives.   Since his time as President of the Institute of Medicine from 2002 to 2014, Dr. Fineberg said he ’s been working toward understanding where and how a patient-centered health system is possible and where the current system is falling short.“Our objective is to improve the experience and outcomes of patient care,” Dr. Fineberg said. His work is centered around a group of patients that often is too diffusely scattered, patients who don’t fall into a single disease category and are not “well caught in our health care system.”“This is a group of patients who have serious illness,” he said. “[They] have one or more long-lasting conditions that is not curable and that changes in an important way your function and your ability to live your life the way you would like.” Though the importance of technology is obvious, Dr. Fineberg said, there is one fundamental driver that is so basic it is often overlooked —demographic and epidemiologic trends.“Two thirds of those today who are age 65 or o...
Source: AMA Wire - Category: Journals (General) Authors: Source Type: news

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Publication date: Available online 22 March 2019Source: Urology Case ReportsAuthor(s): Robert Zakhia El Doueihy, Ibrahim Salti, Marie Maroun-Aouad, Albert El HajjAbstractPheochromocytoma is a sympathetic paraganglioma originating from the chromaffin cells. They are bilateral in 10% of cases and occur as a part of a MEN 2A or 2B syndromes. This is a case of bilateral asymptomatic pheochromocytomas diagnosed incidentally on imaging in a woman being investigated for secondary infertility. Laboratory tests were negative. Whole body FDG scan showed avid uptake of the tracer by both adrenal masses, but none in the thyroid. Hyper...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Authors: Yabut JM, Crane JD, Green AE, Keating DJ, Khan WI, Steinberg GR Abstract Serotonin is a phylogenetically ancient biogenic amine that has played an integral role in maintaining energy homeostasis for billions of years. In mammals, serotonin produced within the central nervous system regulates behavior, suppresses appetite and promotes energy expenditure by increasing sympathetic drive to brown adipose tissue. In addition to these central circuits, emerging evidence also suggests an important role for peripheral serotonin as a factor that enhances nutrient absorption and storage. Specifically, glucose and fa...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research
Publication date: Available online 22 March 2019Source: Journal of Thermal BiologyAuthor(s): Remo Frei, Sean R. Notley, Elizabeth A. Taylor, Catriona A. Burdon, Norikazu Ohnishi, Nigel A.S. TaylorAbstractHerein we describe two experiments in which the recruitment and pressure-induced modifications of human eccrine sweating were investigated. In one experiment, the longstanding belief that glandular recruitment follows a gradual, caudal-to-rostral (dermatomal) recruitment pattern was re-evaluated. The onset of sweating was simultaneously determined (ventilated capsules) from four spinal (dermatomal) segments (forehead, dors...
Source: Journal of Thermal Biology - Category: Biology Source Type: research
Tear film stability assessment is one of the main tests in dry eye diagnosis. However, to date, no test methodology has been adopted as the gold standard due to several reasons, such as the methods being invasive, subjective, or unfeasible for the clinical environment. In this paper, a method that ...
Source: Journal of the Optical Society of America A - Category: Physics Authors: Source Type: research
Conditions:   Essential Hypertension;   Vascular Diseases;   Cardiovascular Diseases Interventions:   Procedure: Renal nerve stimulation, mapping and denervation;   Procedure: Sham Procedure: Renal angiography Sponsor:   The Second Affiliated Hospital of Chongqing Medical University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: April 2019Source: Archives of Cardiovascular Diseases Supplements, Volume 11, Issue 2Author(s): V. Dubes, S. Charron Guitoger, C. Michel, M. Constantin, M. Haissaguerre, M. Hocini, O. Bernus, D. BenoistIntroductionThe right ventricular outflow tract (RVOT) is the main origin of idiopathic ventricular tachycardia (IVTs). Sympathetic stimulation is involved in IVTs but mechanisms underlying this preferential origin remain unknown.ObjectiveTo determine the role of ß1- and ß2-adrenergic receptors (ß1-AR, ß2-AR) in the regional modulation of right ventricular (RV) electrophysiological p...
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
ConclusionsIn summary, our data demonstrate for the first time that in the DMD heart the mitochondrial dysfunction is linked to an excessive SR/ER-mitochondria coupling with an increase in mitochondrial Ca2 + uptake and complex I dysfunction. Such remodeling could be reversed by metformin providing a novel therapeutic perspective in DMD.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
ConclusionMetoprolol afforded a cardioprotective effect on cardiac remodelling and diastolic dysfunction in Iso-induced HF model. Echocardiography and LVEDP measurements validate the reversibility of hypertrophic HF, and Iso-induced HF developed in rat could represent an effective and predictive preclinical model for evaluating antihypertrophic and antifibrotic agents.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
With decreased red reflex and a family history of cataracts, this newborn is in need of a diagnosis. Can you provide it?Medscape Ophthalmology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Ophthalmology Case Challenge Source Type: news
Publication date: Available online 21 March 2019Source: Epilepsy &Behavior Case ReportsAuthor(s): Alejandro Viloria-Alebesque, Elena Bellosta-Diago, Sonia Santos-Lasaosa, José Ángel Mauri-Llerda
Source: Epilepsy and Behavior Case Reports - Category: Neurology Source Type: research
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