A risk of breast cancer in women - carriers of constitutional CHEK2 gene mutations, originating from the North - Central Poland.

CONCLUSION: Obtained results suggest that CHEK2 mutations could potentially contribute to the susceptibility to breast cancer. The germline mutations of CHEK2, especially the truncating ones confer low-penetrance breast cancer predisposition that contribute significantly to familial clustering of breast cancer at the population level.
PMID: 24713400 [PubMed - as supplied by publisher]

Source: Clinical Breast Cancer - April 8, 2014 Category: Cancer & Oncology Authors: B K A, Janiszewska H, Junkiert-Czarnecka A, Heise M, Pilarska-Deltow M, Laskowski R, Pasi Ska M, Haus O Tags: Hered Cancer Clin Pract Source Type: research