The putative Walker A and Walker B motifs of Rrp2 are required for the growth of Borrelia burgdorferi

This article is protected by copyright. All rights reserved. Rrp2 acts in concert with BosR to activate σ54‐dependent rpoS transcription in Borrelia burgdorferi. In contrast to canonical bacterial enhancer binding proteins, Rrp2 is essential for the growth of B. burgdorferi. We demonstrate that the Walker A and B motifs constituting ATP binding and hydrolysis activities of Rrp2 are required for borrelial growth, suggesting that the Walker motifs are involved in Rrp2's control over another unknown RpoS‐independent gene product(s) associated with cell replication.
Source: Molecular Microbiology - Category: Microbiology Authors: Tags: Research Article Source Type: research