Purinergic system dysfunctions in subjects with bipolar disorder: a comparative cross-sectional study

Subjects with bipolar mania may have increased uric acid levels, based on a purinergic system dysfunction with reduced neurotransmission of adenosine. We investigated whether there were differences in uric acid levels between individuals with bipolar disorder (in manic or depressive phases) and those with major depressive disorder.
Source: Comprehensive Psychiatry - Category: Psychiatry Authors: Source Type: research

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We all love and look forward to the holidays, but even good things can be stressful.  Listen in as our guest, PsychCentral.com’s founder, Dr. John Grohol, tells us how to avoid overindulging this year, how to handle the extra work burdens of the season, and how to deal with that annoying relative. SUBSCRIBE &REVIEW Guest information for ‘Holiday Coping’ Podcast Episode John M. Grohol, Psy.D. is a pioneer in online mental health and psychology. Recognizing the educational and social potential of the Internet in 1995, Dr. Grohol has transformed the way people could access mental health and psyc...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Family General Holiday Coping Interview LifeHelper Podcast Relationships Stress The Psych Central Show Source Type: blogs
AbstractAccumulating studies have implicated intracellular signaling through muscarinic acetylcholine receptors (mAChRs) in psychiatric illness. In the present study, carbamylcholine chloride (carbachol)-induced G αi/o and G αq/11 activation was identified in postmortem human prefrontal cortical membranes. The following two sample cohorts were used: subjects [1], consisting of 40 controls without neuropsychiatric disorders, and subjects [2], consisting of 20 with bipolar disorder (BP), 20 major depressive disorder (MDD), 20 schizophrenia, and 20 controls, strictly sex- and age-matched. Carbachol-stimulated [35S...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Neuroscience Source Type: research
AbstractBipolar disorder is an illness characterised by periods of elated and depressed mood. These mood episodes are associated with changes in cognitive function and there is evidence to suggest that cognitive dysfunction persists during euthymia. The extent to which this is a function of the illness or a result of treatment is less clear. In this narrative review, we explore the impact of commonly used medications for bipolar disorder on cognitive function. Specific impairments in executive function and verbal memory have been noted in bipolar disorder. The impact of pharmacological treatments upon cognitive function is...
Source: CNS Drugs - Category: Neurology Source Type: research
Am I an Alcoholic? Alcoholism (also known as Alcohol Use Disorder, or AUD) is a chronic, relapsing disease affecting millions of individuals in the United States. According to the 2017 National Survey on Drug Use and Health (NSDUH), 51 percent of the population aged 12 and older reported binge drinking in the past month. More than 14 million individuals aged 12 and older were suffering from alcoholism. And each year, more than 2,200 individuals die due to alcohol poisoning. Many may come to wonder, “Am I an alcoholic?” What Causes Alcoholism? Some individuals are more prone to alcoholism than others. Alcoholism...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Alcohol Alcoholism alcohol abuse alcohol treatment alcohol treatment center alcohol treatment facility alcoholic alcoholic behavior alcoholics Source Type: blogs
 After receiving two chronic illness diagnosis by the age of 24, it really was no surprise that host Jackie Zimmerman also started to experience depression. Unable to tackle both, Jackie chose to focus on her physical health, letting her mental health deteriorate quickly — and dangerously. In this episode, we discuss the mind-body connection and how when your body is sick, your mind can quickly follow.   (Transcript Available Below) SUBSCRIBE &REVIEW About The Not Crazy Podcast Hosts Gabe Howard is an award-winning writer and speaker who lives with bipolar disorder. He is the author of the popular bo...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Antidepressant Depression Medications Not Crazy Podcast Stress Suicide Trauma Source Type: blogs
This cohort study examines whether individuals with autism spectrum disorder are at greater risk for comorbid diagnoses of depression, anxiety, or bipolar disorder.
Source: JAMA Pediatrics - Category: Pediatrics Source Type: research
This article reviews the candidate genes for MDD and BD, genetic variation loci, chromosome structural variation, new technologies, and new methods. PMID: 31784956 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
CONCLUSION: Our findings show the potential of machine learning models to aid in clinical practice, leading to more objective assessment. Future studies will examine the possibility of combining peripheral blood biomarker data with other biological data to develop more accurate signatures. PMID: 31789053 [PubMed - as supplied by publisher]
Source: The Australian and New Zealand Journal of Psychiatry - Category: Psychiatry Authors: Tags: Aust N Z J Psychiatry Source Type: research
Agitated “unipolar” depression is a clinical entity characterized by excitement together with depressed mood during the same episode. The clinical picture of agitated “unipolar” depression is characterized by a depressed and anxious mood with inner, psychic agitation, whereas motor agitation may or m ay not be present. Some investigators have conceptualized this disorder as a mixed affective state, laying on the bipolar disorder spectrum, but controversies still persist. The diagnosis of agitated “unipolar” depression has important prognostic and therapeutic implications, with many clini...
Source: The Psychiatric Clinics of North America - Category: Psychiatry Authors: Source Type: research
(Natural News) A lot of people may think bipolar disorder is depression. This could be because bipolar disorders were once called “manic depression” and featured depressive episodes. However, these two mental health problems have key differences, and understanding the two can help you deal with each. Bipolar disorder is a brain disorder that causes unusual...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
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