Nanoscale Particulate Matter from Urban Traffic Rapidly Induces Oxidative Stress and Inflammation in Olfactory Epithelium with Concomitant Effects on Brain

Author Affiliations open 1Leonard Davis School of Gerontology, 2USC Dornsife College, 3Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA PDF Version (1.4 MB) Abstract About This Article Supplemental Material Background: Rodent models for urban air pollution show consistent induction of inflammatory responses in major brain regions. However, the initial impact of air pollution particulate material on olfactory gateways has not been reported. Objective: We evaluated the olfactory neuroepithelium (OE) and brain regional responses to a nanosized subfraction of urban traffic ultrafine particulate matter (nPM,
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Article October 2016 Source Type: research

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Authors: Larijani B, Foroughi Heravani N, Alavi-Moghadam S, Goodarzi P, Rezaei-Tavirani M, Payab M, Gholami M, Razi F, Arjmand B Abstract Autism spectrum disorders as a group of pediatric neurodevelopmental diseases is a crucial part of the worldwide disabilities which have influence in communication skills, social interactions, and ability to understand the concepts. The precise pathophysiology of autism spectrum disorders due to the abundance of involved mechanisms is unknown. Some of these involved mechanisms are related to genetic factors, chronic neuro inflammation, mitochondrial dysfunction, oxidative stress,...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Hi all! I'm a current CA-2 at a midwest program. I'm in the middle of applications for OB fellowship. Hoping to find others engaging in this process and people with information on OB fellowship programs. I'm having a hard time finding much information prior to my interviews on many of the programs' websites.
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Anesthesiology Source Type: forums
In conclusion, this study found that patients with FES had abnormal functional connectivity in the amygdala subregions, and the altered rsFC was associated with positive symptoms. The present findings demonstrate the disruptive rsFC patterns of amygdala subregional-sensorimotor networks in FES and may provide new insights into the neuronal pathophysiology of FES.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
This study aims at examining the correlation between the pattern of brain atrophy of MCI patients and performance on financial abilities. Forty-four MCI patients and thirty-seven healthy controls underwent structural magnetic resonance imaging, and assessment of financial abilities by means of the Numerical Activities of Daily Living Financial battery (NADL-F). As compared to healthy controls, MCI patients showed impaired performance in three out of the seven domains assessed by NADL-F: Item purchase, percentage, and financial concepts. The patients’ performance in the NADL-F correlated with memory, language, visuo-s...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: March 2020Source: Journal of Vascular and Interventional Radiology, Volume 31, Issue 3, SupplementAuthor(s): R. Le, A. Hoefnagel, J. Yao, D. Rao
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Publication date: March 2020Source: Journal of Vascular and Interventional Radiology, Volume 31, Issue 3, SupplementAuthor(s): B. Choi, H. Jung, B. Yu, H. Choi, J. Lee, D. Kim
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Researchers at the University of Texas Dallas (UTD) are playing with alchemy by transforming a virus into an organic radical contrast agent (ORCA), an alternative to gadolinium-based contrast agents to be used in magnetic resonance imaging (MRI) procedures. ORCA molecules had been previously considered too dim for scanning and were easily eradicated by vitamin C in the body. UTD researchers found that by connecting the molecules to a  tobacco mosaic virus, a virus that attacks plant cells and disrupts cell activity, they were able to eliminate those issues and make the ORCA an effective agent. Once the ORCA ...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
Yale New Haven Hospital is under fire from federal prosecutors for allegations that the prestigious medical center ’sLate Career Practitioner Policy discriminates and humiliates older physicians. This month, the Equal Employment Opportunity Commission (EEOC) filed a lawsuit against the hospital accusing them of forcing radiologists to submit to neuropsychological and eye exams in order to keep their staff privileges. Physicians under 70 were not obligated to undergo these evaluations. The EEOC claimed that Yale ’s policy was enacted regardless of suspicions that doctors were experiencing neurological ...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
Conclusions: Radial head arthroplasty with a monoblock UHMW-PE RHP is safe and effective at short-term follow-up for treating acute unreconstructable radial head fractures with satisfactory functional and radiographic outcomes. Level of Evidence: Level IV.
Source: Current Orthopaedic Practice - Category: Orthopaedics Tags: Special Focus: Trauma Source Type: research
Background: Total hip arthroplasty (THA) is an effective treatment for symptomatic osteoarthritis after failed nonsurgical therapies. Minimizing perioperative complications is critical for faster recovery and shorter hospital stay. The primary aim of this study was to identify predictors of perioperative major complications (MC) and mortality after THA, and to use these predictors to develop a risk scoring system. Methods: The 2006-2016 National Surgical Quality Improvement Program (NSQIP) database was queried for adult patients who underwent primary elective THA performed under general or neuraxial anesthesia. Univar...
Source: Current Orthopaedic Practice - Category: Orthopaedics Tags: Original Research Source Type: research
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