Scientific Issues Relevant to Setting Regulatory Criteria to Identify Endocrine-Disrupting Substances in the European Union

Conclusions: There is scientific agreement regarding the adequacy of the WHO definition of EDs. The potency concept is not relevant to the identification of particularly serious hazards such as EDs. As is common practice for carcinogens, mutagens, and reproductive toxicants, a multi-level classification of ED based on the WHO definition, and not considering potency, would be relevant (corresponding to option 3 proposed by the European Commission).

Citation: Slama R, Bourguignon JP, Demeneix B, Ivell R, Panzica G, Kortenkamp A, Zoeller RT. 2016. Scientific issues relevant to setting regulatory criteria to identify endocrine disrupting substances in the European Union. Environ Health Perspect 124:1497–1503; http://dx.doi.org/10.1289/EHP217
Address correspondence to R. Slama, Team of environmental epidemiology, IAB / Inserm-CNRS-Univ Grenoble-Alpes (U1209) joint research center, Site Santé, Allée des Alpes, F-38700 La Tronche (GRENOBLE), France. Telephone: [phone]. E-mail: [e-mail]
R.S., J.P.B., B.D., R.I., G.P., and T.Z. have had travel fees covered by the Endocrine Society (a nonprofit organization) for travel and accommodation expenses to meetings related to endocrine disruptors.
The authors declare they have no actual or potential competing financial interests.
Received: 14 September 2015
Revised: 17 February 2016
Accepted: 5 April 2016
Published: 25 April 2016
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Source: EHP Research - September 30, 2016 Category: Environmental Health Authors: Web Admin Tags: Commentary October 2016 Source Type: research