Study: Onconase, Malaria Drug Extends Mesothelioma Survival
A new treatment combining two existing drugs — one derived from frog eggs and another given to combat malaria — may be the key to extending mesothelioma survival. Scientists at Tongji University in Shanghai, China, discovered that mixing Onconase, an enzyme present in early-stage leopard frog embryos, with antimalarial drug dihydroartemisinin (DHA) synergistically suppressed growth and angiogenesis of malignant mesothelioma, an aggressive cancer linked to asbestos exposure. Researchers investigated the antitumor effects of the drug combination in two ways — in vitro (in a test tube) and in vivo (in a living organism). Scientists found DHA significantly enhanced the antitumor effect of Onconase in nude mice, a type of rodent used in lab tests, inoculated with cancer cells. The density of tumor tissue in those mice was also lower in comparison to the mice treated with Onconase or DHA alone. The results were also consistent with the Matrigel plug assay, a quick and easy test for evaluating angiogenic (growth of new blood vessels) and antiangiogenic (substances that inhibit growth) compounds in vivo. Researchers said the treatment showed no obvious adverse effects, unlike a combination of Onconase and Adriamycin, a drug tested for malignant mesothelioma in the U.S. The side effects included weight loss, physical weakness, temperature drop, partial or complete loss of muscle movement and diarrhea. “Biochemical analyses of blood samples did not reveal si...
Date: Thursday, 04 09, 2020; Speaker: Zeynup Gumus, Assistant Professor, Ichan School of Medicine at Mount Sinai; https://cbiit.webex.com/mw3300/mywebex/default.do?
A group of moderately ill people were given hydroxychloroquine, which appeared to ease their symptoms quickly, but more research is needed.
Publication date: Available online 31 March 2020Source: Materials Today: ProceedingsAuthor(s): G. Sai Krishnan, S. Kumar, G. Suresh, N. Akash, V. Sathish Kumar, J.P. David
Publication date: 31 March 2020Source: Cell Reports, Volume 30, Issue 13Author(s): Tugba Keskin, Arnaud Bakaric, Patricia Waszyk, Gaylor Boulay, Matteo Torsello, Sandrine Cornaz-Buros, Nadja Chevalier, Thibaud Geiser, Patricia Martin, Angela Volorio, Sowmya Iyer, Anupriya Kulkarni, Igor Letovanec, Stéphane Cherix, Gregory M. Cote, Edwin Choy, Antonia Digklia, Michael Montemurro, Ivan Chebib, Petur G. Nielsen
Publication date: Available online 31 March 2020Source: CellAuthor(s): Marcus Ruscetti, John P. Morris, Riccardo Mezzadra, James Russell, Josef Leibold, Paul B. Romesser, Janelle Simon, Amanda Kulick, Yu-jui Ho, Myles Fennell, Jinyang Li, Robert J. Norgard, John E. Wilkinson, Direna Alonso-Curbelo, Ramya Sridharan, Daniel A. Heller, Elisa de Stanchina, Ben Z. Stanger, Charles J. Sherr, Scott W. Lowe
Publication date: Available online 31 March 2020Source: Clinica Chimica ActaAuthor(s): Andras Komaromy, Balazs Reider, Gabor Jarvas, Andras Guttman
Publication date: Available online 31 March 2020Source: Clinica Chimica ActaAuthor(s): Yueting Xiong, Chao Shi, Xiaohui Liu, Pengyuan Yang
Matthew FeeneyDeadly misinformation spread across social media long before COVID-19 emerged, but amid the ongoing pandemic attempts to tackle such content are once again in the limelight. These efforts provide an opportunity for classical liberals to emphasize the importance of freedom of association and to prepare for discussions about how private institutions handle misinformation amid a crisis.Too often we think of the freedom of speech to be a freedom that protects speakers from government censorship. And while the freedom to speak is a necessary condition for a functioning liberal society it&rsqu...
Authors: Ahmadianpour MV, Mowla J, Sotoodehnejadnematalahi F, Raheb J Abstract Studies on the blood of patients with prostate cancer using Dynamic Light Scattering (DLS) and corona protein size changes have shown that this test is highly specific and sensitive, but this method has not been studied in Iran, and therefore this study intends to perform this procedure using gold nanoparticles in prostate cancer detection. Blood samples of 60 male subjects aged 40-90 years were collected from 20 healthy, 20 benign and 20 prostate cancer patients. Optical scattering changes were measured by the level of gold nanoparticle...
DISCUSSION These findings suggest that hunger training could be translated to primary care with minor modifications. PMID: 32223854 [PubMed - in process]
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