Study: Onconase, Malaria Drug Extends Mesothelioma Survival

A new treatment combining two existing drugs — one derived from frog eggs and another given to combat malaria — may be the key to extending mesothelioma survival. Scientists at Tongji University in Shanghai, China, discovered that mixing Onconase, an enzyme present in early-stage leopard frog embryos, with antimalarial drug dihydroartemisinin (DHA) synergistically suppressed growth and angiogenesis of malignant mesothelioma, an aggressive cancer linked to asbestos exposure. Researchers investigated the antitumor effects of the drug combination in two ways — in vitro (in a test tube) and in vivo (in a living organism). Scientists found DHA significantly enhanced the antitumor effect of Onconase in nude mice, a type of rodent used in lab tests, inoculated with cancer cells. The density of tumor tissue in those mice was also lower in comparison to the mice treated with Onconase or DHA alone. The results were also consistent with the Matrigel plug assay, a quick and easy test for evaluating angiogenic (growth of new blood vessels) and antiangiogenic (substances that inhibit growth) compounds in vivo. Researchers said the treatment showed no obvious adverse effects, unlike a combination of Onconase and Adriamycin, a drug tested for malignant mesothelioma in the U.S. The side effects included weight loss, physical weakness, temperature drop, partial or complete loss of muscle movement and diarrhea. “Biochemical analyses of blood samples did not reveal si...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: antitumor extending mesothelioma survival malaria drug malignant pleural mesothelioma mesothelioma clinical trial mesothelioma treatment onconase onconase clinical trial tongji university Source Type: news

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