Pediatric Anaphylaxis Study Lacks Crucial Details

The Research Carrillo E, Hern HG, Barger J. Prehospital administration of epinephrine in pediatric anaphylaxis. Prehosp Emerg Care. 2016;20(2):239–244. The Science To assess the rates of administration of epinephrine, diphenhydramine (Benadryl) and albuterol to children with allergic reactions including anaphylaxis, the authors reviewed the EMS records of Contra Costa County and Alameda County in California from January 2010 to July 2011. Combined, the two counties serve a population of about 2.3 million people. Of the slightly more than 239,000 patient contacts and 13,000 pediatric transports, paramedics treated 205 pediatric patients with allergic complaints; 98 of these cases had signs and symptoms consistent with anaphylaxis and therefore would be candidates to the administration of epinephrine. However, only 53 (54%) were given epinephrine either by EMS or prior to the arrival of EMS. Of those not given epinephrine prior to EMS arrival, only six (12%) received epinephrine by EMS, 10 (20%) received only diphenhydramine, nine (18%) received only albuterol, and 17 (33%) received both albuterol and diphenhydramine. Nine (18%) of the patients received no treatment prior to hospital arrival. Patients with a history of anaphylaxis were more likely to receive epinephrine than those without a history (45% vs. 5%, respectively). Medic Wesley Comments I read this study twice to be sure that I hadn't missed the ultimate goal of patient outcomes. It wasn't there.
Source: JEMS Patient Care - Category: Emergency Medicine Authors: Tags: Columns Patient Care Source Type: news

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Anaphylaxis is a severe allergic reaction that can potentially lead to death if not promptly treated. Allergic reactions typically begin suddenly after exposure to an allergen, which may be a food, medication, insect sting, or another trigger. Anaphylaxis can occur in anyone at any time; it can sometimes be triggered by allergens that a person has only had mild reactions to in the past — or to which they have never reacted to before. Recognizing anaphylaxis A mild allergic reaction may consist of hives, itching, flushing, swelling of the lips or tongue, or some combination of these. However, throat swelling or tighte...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Allergies Emergency Planning Source Type: blogs
This study aimed at estimating the distributions of capsular polysaccharide (CPS) types and pilus profiles, and the rates of antimicrobial resistance among GBS strains isolated from colonized pregnant women and newborns in 2010 –2011 and 2017–2018 in St. Petersburg, Russia. A total of 261 GBS isolates have been investigated. Antibiotic susceptibility testing was performed using the disc-diffusion method. CPS types and pilus profiles were determined by using PCR. Over the 9-year period, the resistance of GBS to both ery thromycin and clindamycin has significantly increased, exceeding 30% in 2017–2018. The ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Nicola Mucci Allergic disorders in the agriculture sector are very common among farm workers, causing many injuries and occupational diseases every year. Agricultural employees are exposed to multiple conditions and various allergenic substances, which could be related to onset of anaphylactic reactions. This systematic review highlights the main clinical manifestation, the allergens that are mostly involved and the main activities that are usually involved. This research includes articles published on the major databases (PubMed, Cochrane Library, Scopus), using a combination of keywords. The online search yielded 48...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
Authors: de la Fuente J, Cabezas-Cruz A, Pacheco I Abstract INTRODUCTION: The α-Gal syndrome (AGS) is a type of allergy characterized by an IgE antibody response against the carbohydrate Galα1-3Galβ1-4GlcNAc-R (α-Gal). Tick bites are recognized as the most important cause of anti-α-Gal IgE antibody increase in humans. Several risk factors have been associated with the development of AGS, but their integration into a standardized disease diagnosis has proven challenging. AREAS COVERED: Herein we discuss the current AGS diagnosis based on anti-α-Gal IgE titers and propose an alg...
Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research
We present evidence that NF-κB-miR-183-5p-BTG1 axis can serve as target for development of anti-allergy drug.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
PMID: 32618350 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research
AbstractCationic arginine-rich peptides represent a novel class of peptides being developed as neuroprotective agents for stroke and other acute and chronic neurological disorders. As a group, cationic arginine-rich peptides have a diverse range of other biological properties including the ability to traverse cell membranes, modulate immune responses, antagonise ion channel receptor function, as well as possessing cardioprotective, anti-nociceptive, anti-microbial and anti-cancer properties. A sound understanding of their safety profile is essential for the design of future clinical trials and for ensuring translational su...
Source: Drug Safety - Category: Drugs & Pharmacology Source Type: research
Food allergy (FA) is a chronic condition of emerging global concern. Surveys have been conducted in numerous countries to assess physician knowledge, attitude, and practices (KAP) pertaining to FA and anaphylaxis and substantial deficits in their KAP were identified.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Special Series Source Type: research
Publication date: Available online 27 June 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Polloni Laura, Bonichini Sabrina, Ronconi Lucia, Bonaguro Roberta, Lazzarotto Francesca, Toniolo Alice, Muraro Antonella
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
AbstractPurpose of ReviewShrimp and other crustaceans and molluscs are one of the most frequent causes of food allergy and anaphylaxis at all ages. Molecular biology has paved the way to a better understanding of the allergen profile of invertebrates that is much more complex than thought only one decade ago.Recent FindingsWhile tropomyosin has been traditionally considered as the dominating major allergen in crustaceans and other invertebrates, recent research demonstrated that IgE to this allergen can be detected in about 50% of shrimp-allergic patients only. Many of these allergens are conserved ones and, hence, potenti...
Source: Current Treatment Options in Allergy - Category: Allergy & Immunology Source Type: research
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