Impact of CHA2DS2VASc Score on Candidacy for Anticoagulation in Patients With Atrial Fibrillation: A Multipayer Analysis.
Impact of CHA2DS2VASc Score on Candidacy for Anticoagulation in Patients With Atrial Fibrillation: A Multipayer Analysis. Clin Ther. 2016 Sep 23; Authors: Patel AA, Nelson WW, Schein J Abstract PURPOSE: The purpose of this study is to report on the effect of using CHA2DS2VASc (congestive heart failure, hypertension, age ≥75 years [doubled], type 1 or type 2 diabetes mellitus, stroke or transient ischemic attack or thromboembolism [doubled], vascular disease [prior myocardial infarction, peripheral artery disease, or aortic plaque], age 65-75 years, sex category [female]) rather than CHADS2 (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, and prior stroke) to determine candidacy for anticoagulant prophylaxis in insured patients with atrial fibrillation (AF). METHODS: Six administrative claims databases that included medical and pharmacy claims for patients aged ≥18 years with a new or existing diagnosis of AF and patient outcomes assessed for 1 year after diagnosis were analyzed. Retrospective health plan data analyses were performed using a software tool (Anticoagulant Quality Improvement Analyzer). Study measures included stroke risk (identified by CHADS2 and CHA2DS2VASc scores), bleeding risk (identified by the Anticoagulation and Risk Factors in Atrial Fibrillation score), and anticoagulant use. FINDINGS: A total of 115,906 patients with AF (range of mean ages among the 6 databases, 56-79 years) met the inc...
Publication date: Available online 22 January 2020Source: Genes &DiseasesAuthor(s): Sergei N. Orlov, Artem M. Tverskoi, Svetlana V. Sidorenko, Larisa V. Smolyaninova, Olga D. Lopina, Nickolai O. Dulin, Elizaveta A. KlimanovaAbstractWith an exception of few reports, the plasma concentration of ouabain and marinobufagenin, mostly studied cardiotonic steroids (CTS) assessed by immunoassay techniques, is less than 1 nM. During the last 3 decades, the implication of these endogenous CTS in the pathogenesis of hypertension and other volume-expanded disorders is widely disputed. The threshold for inhibition by CTS of human an...
Publication date: Available online 21 January 2020Source: Genes &DiseasesAuthor(s): W.E.I. Zilun, Y.A.N.G. Yining, L.I. Qiaoling, Y.I.N. Yong, W.E.I. Zhonghai, Z.H.A.N.G. Wenfeng, M.U. Dan, N.I. Jie, S.U.N. Xuan, X.U. BiaoAbstract and KeywordsHypertension (HT) is the most common public-health challenge and shows a high incidence around the world. Cardiovascular diseases are the leading cause of mortality and morbidity among the elderly (age> 65 years) in the United States. Now, there is widespread acceptance of the causal link between HT and acute myocardial infarction (MI). This is the first data-mining study to id...
People who undergo gastric bypass surgery are more likely to achieve remission of diabetes than those who try to lose weight by dieting and exercising, researchers say.Reuters Health Information
CONCLUSIONS: The novel Genoss DES™ stent exhibited excellent safety and efficacy in real-world practice. PMID: 31960640 [PubMed - as supplied by publisher]
The objective of this study was to evaluate the long-term clinical outcomes and the incidence of permanent pacemaker implantation after catheter ablation in patients with of atrial fibrillation (AF) and sinus node dysfunction (SND). METHODS: Among 3,068 total consecutive patients who underwent AF catheter ablation (AFCA), this study included 222 (9.5%; men 53.2%, 63.7±9.2 years of age, 81.5% paroxysmal AF) with underlying SND and a regular rhythm follow-up. We analyzed the rhythm outcomes, changes in the mean heart rate or heart rate variability, and permanent pacemaker implantation rate. RESULTS: During 47....
Authors: Mohandes M, Pernigotti A, Morr CI, Bardají A PMID: 31960636 [PubMed - as supplied by publisher]
Authors: Shin DG, Lim HE PMID: 31960634 [PubMed]
Authors: Yoon CH PMID: 31960633 [PubMed]
Authors: Suh JW PMID: 31960632 [PubMed]
More News: Atrial Fibrillation | Bleeding | Cardiology | Congestive Heart Failure | Databases & Libraries | Diabetes | Diabetes Mellitus | Diabetes Type 1 | Diabetes Type 2 | Endocrinology | Health | Heart | Heart Attack | Heart Failure | Hypertension | Insurance | Ischemic Stroke | Peripheral Vascular Disease (PVD) | Stroke | Study | Thrombosis