Changes in Endocannabinoid Receptors and Enzymes in the Spinal Cord of SOD1(G93A) Transgenic Mice and Evaluation of a Sativex(®) -like Combination of Phytocannabinoids: Interest for Future Therapies in Amyotrophic Lateral Sclerosis.
CONCLUSIONS: Our results demonstrated changes in endocannabinoid signaling, in particular a marked up-regulation of CB2 receptors, in SOD1(G93A) transgenic mice, and provide support that Sativex(®) may serve as a novel disease-modifying therapy in ALS.
PMID: 24703394 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Moreno-Martet M, Espejo-Porras F, Fernández-Ruiz J, de Lago E Tags: CNS Neurosci Ther Source Type: research