Involvement of Aquaporin 4 in Astrocyte Function and Neuropsychiatric Disorders.

Involvement of Aquaporin 4 in Astrocyte Function and Neuropsychiatric Disorders. CNS Neurosci Ther. 2014 Apr 8; Authors: Xiao M, Hu G Abstract Aquaporin 4 (AQP4) is the main water channel in the central nervous system (CNS) and specifically localized to astrocyte processes. Recent studies indicate that AQP4 regulates various biological functions of astrocytes, including maintaining CNS water balance, spatial buffering of extracellular potassium, calcium signal transduction, regulation of neurotransmission, synaptic plasticity, and adult neurogenesis, while under neuropathological conditions, AQP4 has a role in astrogliosis and proinflammatory cytokine secretion. In addition, accumulating evidence suggests that, besides cerebral edema, neuromyelitis optica and epilepsy, AQP4 participates in the onset and progression of Alzheimer disease, Parkinson disease, depression, and drug addiction. This review summarizes recent findings and highlights the involvement of AQP4 in astrocyte function and neuropsychiatric disorders. PMID: 24712483 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Tags: CNS Neurosci Ther Source Type: research

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Dalton Trans., 2019, Accepted Manuscript DOI: 10.1039/C9DT03332G, CommunicationZhuxiu Zhang, Yue Xiao, Mi Fen Cui, Jihai Tang, Zhaoyang Fei, Liu Qing, Xian Chen, Xu Qiao Fine-tuning of the metal-based molecular building blocks in Zn-MOF-74 through post-synthetic cation exchange with Ca2+ significantly enhance the basicity and corresponding catalytic performance. The resulting material, exemplified by the Ca/Zn-MOF-74,... The content of this RSS Feed (c) The Royal Society of Chemistry
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ConclusionsThis study shows that a relapse is accompanied by an increase in MS-related fatigue. Moreover, autonomic dysfunctions and introversion, more than depression and apathy, play a major role in the explanation of MS-related fatigue. This finding represents additional evidence for the relationship between inflammation, vagal afferent signalling, autonomic dysfunctions, introversion and the feeling of MS-related fatigue.KeywordsMultiple Sclerosis, fatigue, relapse, autonomic dysfunctions, vagal afferents
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: December 2019Source: Research in Autism Spectrum Disorders, Volume 68Author(s): A. Muskett, N.N. Capriola-Hall, S. Ryan Radtke, R. Factor, A. ScarpaAbstractYouth with Autism Spectrum Disorder (ASD) experience depression and anxiety at higher rates than typically developing (TD) youth. The current study examined how restricted and repetitive behaviors or interests (RRBs) may be related to symptoms of depression and anxiety. Participants included 35 children with ASD (29 male, 6 female) between 3 and 14 years. Youth who met clinical cut-off for depression and anxiety demonstrated increased self-injurious be...
Source: Research in Autism Spectrum Disorders - Category: Psychiatry Source Type: research
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The families will hold up a giant invoice outside the DoH for the £231,000 they have collectively spent on the private prescriptions for their children. They'll then deliver handwritten letters to Downing Street.
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Source: Frontiers in Physiology - Category: Physiology Source Type: research
Abstract Lycopene is an aliphatic hydrocarbon carotenoid extracted from plants like tomatoes, papayas, and watermelons. Previous studies have shown that lycopene can exert prophylactic and/or therapeutic effects in different disorders, such as heart failure and neoplasm via anti-oxidative, anti-inflammatory, and anti-proliferative activities. In the central nervous system (CNS), lycopene also has prophylactic and/or therapeutic effects in different type of disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), cerebral ischemia, epilepsy, and depression. Lycopene also imp...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
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