New Theory on How Insulin Resistance, Metabolic Disease Begin

Contact: Samiha KhannaPhone: 919-419-5069Email:samiha.khanna@duke.eduhttps://www.dukehealth.orgEMBARGOED FOR RELEASE until 4 p.m. (ET) on Monday, Sept. 26, 2016DURHAM, N.C. -- Does eating too much sugar cause type 2 diabetes?The answer may not be simple, but a study published Sept. 26 in the Journal of Clinical Investigation adds to growing research linking excessive sugar consumption -- specifically the sugar fructose -- to a rise in metabolic disease worldwide.The study, conducted in mice and corroborated in human liver samples, unveils a metabolic process that could upend previous ideas about how the body becomes resistant to insulin and eventually develops diabetes.  The increasing prevalence of diabetes is considered a health epidemic as more than 29 million people in the U.S. have diabetes and another 86 million have pre-diabetes, according to the Centers for Disease Control and Prevention.“There is still significant controversy as to whether sugar consumption is a major contributor to the development of diabetes,” said senior authorMark Herman, M.D., assistant professor in the Division of Endocrinology, Metabolism, and Nutrition at Duke University School of Medicine.“Some investigators contend that commonly consumed amounts of sugar do not contribute to this epidemic,” Herman said. “While others are convinced that excessive sugar ingestion is a major cause. This paper reveals a specific mechanism by which consuming fructose in large a...
Source: DukeHealth.org: Duke Health Features - Category: Pediatrics Tags: Duke Medicine Source Type: news

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CORRIGENDUM FOR "Reductions in Insulin Resistance are Mediated Primarily via Weight Loss in Subjects With Type 2 Diabetes on Semaglutide". J Clin Endocrinol Metab. 2020 Jan 01;105(1): Authors: PMID: 31832679 [PubMed - in process]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Tags: J Clin Endocrinol Metab Source Type: research
ERRATUM FOR "Serum Lipids in Association With Type 2 Diabetes Risk and Prevalence in a Chinese Population". J Clin Endocrinol Metab. 2020 Jan 01;105(1): Authors: PMID: 31832675 [PubMed - in process]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Tags: J Clin Endocrinol Metab Source Type: research
This study summarizes the literature evaluating the impact of CPs in the management of PLWH in the era of modern ART. We conducted a literature search to identify studies that assessed the CP role in HIV clinical practice since 2006. The identified studies were grouped into two categories. The first was HIV related outcomes, including interventions on regimen selection, adherence, regimen optimization, and management of treatment failure. The second group of studies pertained to aging and vulnerable populations, including management of comorbidities, transitions of care, medication-assisted treatment, hepatitis C, and HIV ...
Source: AIDS Reviews - Category: Infectious Diseases Authors: Tags: AIDS Rev Source Type: research
, Jacobo-García K, Cossio-Aranda J Abstract Heart failure (HF) is a syndrome characterized basically by a circulatory deficit to cover the metabolic and energetic demands of the body. This condition has a broad spectrum in its clinical presentation, affects the quality of life significantly, impacts the family/social environment, and generates a great demand for health services. The purpose of this research is to report the situational diagnose of patients with HF in Mexico. We evaluated 292 patients, 70.2% were men. Average age was 56.7 ± 14.3 years. Ischemic heart disease is the main etiology (98 p...
Source: Archivos de Cardiologia de Mexico - Category: Cardiology Authors: Tags: Arch Cardiol Mex Source Type: research
We examined trends in and comorbid conditions associated with hospitalizations and in-hospital mortality in the setting of AKI-D among people with versus without diabetes.Study DesignCross-sectional study.Setting &ParticipantsNationally representative data from the National Inpatient Sample and National Health Interview Survey were used to generate 16 cross-sectional samples of US adults (aged ≥18 years) between 2000 and 2015.ExposureDiabetes, defined using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) diagnosis codes.OutcomeAKI-D, defined using ICD-9-CM diagnos...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
ConclusionThe lower involvement of brain regions observed in Takotsubo patients suggests an impairment in emotional regulation, which might be of etiological importance in this brain-heart disease.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
ConclusionThese results suggest that fish oil addition on top of an atherogenic, HF diet, is beneficial, while olive oil is not, in its effect on plaque formation and NAFLD in LDLR KO mice.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
ConclusionTreatment with liraglutide decreases REE in the first 12 weeks and tends to decrease this after 26 weeks without affecting the fat fraction in the supraclavicular BAT depot. These findings suggest reduction in energy intake rather than an increase in REE to contribute to the liraglutide-induced weight loss.Trial registry numberNCT01761318.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Publication date: 8 March 2017 Source:Neurocomputing, Volume 228 Author(s): Paul Fergus, Abir J. Hussain, John Hearty, Stuart Fairclough, Lynne Boddy, Kelly Mackintosh, Gareth Stratton, Nicky Ridgers, Dhiya Al-Jumeily, Ahmed J. Aljaaf, Jenet Lunn The growing trend of obesity and overweight worldwide has reached epidemic proportions with one third of the global population now considered obese. This is having a significant medical impact on children and adults who are at risk of developing osteoarthritis, coronary heart disease and stroke, type 2 diabetes, cancers, respiratory problems, and non-alcoholic fatty liver disease...
Source: Neurocomputing - Category: Neuroscience Source Type: research
I tell my patients to avoid drinking soda not just because they make you fat. Each sip of soda affects your health. Soda puts you at risk for health problems like metabolic syndrome. This is a collection of symptoms that can lead to diabetes, heart disease and other chronic diseases, like cancer. Soft drinks are the beverage of choice for millions of Americans. The latest research now reveals that sodas are a major cause of visceral fat — the deadliest kind of fat you can have, inflaming your tissues, rotting your blood vessels and upsetting your body chemistry. In a minute I’m going to tell you about a great ...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Heart Health heart disease metabolic syndrome Visceral Fat Source Type: news
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