Combined glutamate and glutamine levels in pain-processing brain regions are associated with individual pain sensitivity

Abstract: The relationship between glutamate and γ-aminobutyric acid (GABA) levels in the living human brain and pain sensitivity is unknown. Combined glutamine/glutamate (Glx), as well as GABA levels can be measured in vivo with single-voxel proton magnetic resonance spectroscopy. In this cross-sectional study, we aimed at determining whether Glx and/or GABA levels in pain-related brain regions are associated with individual differences in pain sensitivity. Experimental heat, cold, and mechanical pain thresholds were obtained from 39 healthy, drug-free individuals (25 men) according to the quantitative sensory testing protocol and summarized into 1 composite measure of pain sensitivity. The Glx levels were measured using point-resolved spectroscopy at 3 T, within a network of pain-associated brain regions comprising the insula, the anterior cingulate cortex, the mid-cingulate cortex, the dorsolateral prefrontal cortex, and the thalamus. GABA levels were measured using GABA-edited spectroscopy (Mescher–Garwood point-resolved spectroscopy) within the insula, the anterior cingulate cortex, and the mid-cingulate cortex. Glx and/or GABA levels correlated positively across all brain regions. Gender, weekly alcohol consumption, and depressive symptoms were significantly associated with Glx and/or GABA levels. A linear regression analysis including all these factors indicated that Glx levels pooled across pain-related brain regions were positively associated with pain se...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research

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While recreational marijuana is legal in 11 states as of November 2019, more states gravitating toward legalizing the recreational use of the substance, and 33 states allowing medical marijuana, there’s apparently no stopping this trend. Cannabis, in the form of marijuana, hemp, and cannabidiol (CBD)  is being used for pain relief, to alleviate stress, cope with anxiety, and a number of other mental health disorders and addictions. Yet, there’s a dearth of clinical studies that have been conducted on the overall effects on a user’s health. Clearly, as Crain’s Detroit Business points out, more ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Medications Substance Abuse Cannabis Marijuana Source Type: blogs
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ConclusionsA history of MST is common among older women veterans and associated with a range of medical and mental health diagnoses. These findings call attention to the need for additional research in this understudied population, and the importance of trauma-informed care approaches for women across the lifespan.
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
Your Guide to Vicodin Addiction and Vicodin Withdrawal Hydrocodone (also known by the brand name Vicodin®) has been the second-most commonly encountered opioid pharmaceutical in drug evidence since 2009, as reported by the Drug Enforcement Administration (DEA). Withdrawal from Vicodin can vary in length and symptoms depending on the length and severity of the addiction. Vicodin is relatively easy to obtain and is perceived as safe when prescribed by a medical professional. If the drug is taken as prescribed for a limited time, Vicodin withdrawal symptoms will be either minimal or nonexistent. However, Vicodin is consid...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Recovery Drug Treatment Painkiller Substance Abuse painkillers prescription drug abuse prescription drug addiction prescription drug detox prescription drug use prescription drugs prescription medication prescription pills Source Type: blogs
A 19-year-old woman with suicidal thoughts consumed 24 anhydrous caffeine tablets and was admitted to our hospital. After being discharged from the hospital, her oral intake remained impaired because of retrosternal pain and she was readmitted. An upper ga...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
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Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
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Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
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Source: Current Emergency and Hospital Medicine Reports - Category: Emergency Medicine Source Type: research
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