A novel intrinsic analgesic mechanism: the enhancement of the conduction failure along polymodal nociceptive C-fibers

In this study, we extend this finding in the complete Freund's adjuvant model of inflammatory pain and validate that the degree of conduction failure decreased and led to a greater amount of pain signals conveyed to the central nervous system. In complete Freund's adjuvant–injected animals, conduction failure occurred in a C-fiber-selective, activity-dependent manner and was associated with an increase in the rising slope of the C-fiber after-hyperpolarization potential. To target conduction failure in a therapeutic modality, we used ZD7288, an antagonist of hyperpolarization-activated, cyclic nucleotide–modulated channels which are activated by hyperpolarization and play a pivotal role in both inflammatory and neuropathic pain. ZD7288 promoted conduction failure by suppressing Ih as a mechanism to reduce the rising slope of the after-hyperpolarization potential. Moreover, perineuronal injection of ZD7288 inhibited abnormal mechanical allodynia and thermal hyperalgesia without affecting motor function or heart rate. Our data highlight the analgesic potential of local ZD7288 application and identify conduction failure as a novel target for analgesic therapeutic development.
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research

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Source: Journal of Pain Research - Category: Anesthesiology Tags: Journal of Pain Research Source Type: research
Condition:   Neuropathy, Diabetic Interventions:   Behavioral: Progressive muscle relaxation;   Behavioral: Mindfulness meditation;   Other: Attention matched control Sponsor:   Hacettepe University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: Our article draws attention to the higher cardiovascular risk profile of middle-aged migraineurs and highlights the deficiency of primary prevention. Pain physicians must be aware of the cardiovascular aspects of migraine and holistic approach is required instead of focusing only on pain and pain relief. PMID: 32089752 [PubMed - in process]
Source: Behavioural Neurology - Category: Neurology Authors: Tags: Behav Neurol Source Type: research
Every year in the United States, the CDC estimates that influenza results in between 9 million – 45 million illnesses, between 140,000 – 810,000 hospitalizations, and between 12,000 – 61,000 deaths (approximately 100  – 200 being pediatric fatalities). In the United States, the immense disease burden of the flu is unparalleled with any other pathogen, but fortunately there is a vaccine and antiviral medications which help to mitigate the yearly morbidity and mortality wrought by influenza.Because the flu changes its shape every year by a process called antigenic shift&n...
Source: A Pediatrician's Blog - Category: Pediatrics Source Type: blogs
In conclusion, 10 kHz SCS treatment resulted in significant pain relief in all the patients, decreased reliance on pain medication and improved lower limb sensory function in majority of patients. PMID: 32073352 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
AbstractBackground/aimDiabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus (DM). The Michigan Neuropathy Screening Instrument (MNSI) is a simple, brief, and useful screening tool that was designed to assess DPN. The aim of this study was to develop a Turkish version of the MNSI and assess its reliability and validity.Materials and methodsEighty-three patients with DM who were divided into two groups according the results of nerve conduction studies (NCS) as having DPN or without DPN were enrolled in this cross-sectional study. The Toronto clinical scoring system, pain detect questionnai...
Source: Diabetology International - Category: Endocrinology Source Type: research
Mrs Havercampa presents to clinic at 4:00 pm today for an unscheduled appointment. She is a 67-year-old obese diabetic woman who is 10  days status post right common femoral endarterectomy with Dacron patch angioplasty and retrograde iliac stenting for rest pain. Today, she reports increasing pain and drainage from the groin wound. On examination, there is erythema and dehiscence of the skin edges. Cloudy fluid emanates from the w ound. I sigh. “Mrs Havercamp, when was the last time you had anything to eat or drink?”
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Invited commentary Source Type: research
Had a weird case a couple of weeks ago. My partner, who is an outstanding technical surgeon for implants (one of the best I have seen) had a stim follow up while he was on vacation. The wounds were dehiscing and the incisions looked odd (my partner has had only two infections over a 25 year career, so he is pretty damn good). I took her to the OR and removed the stim, packing the incisions open. Initial cultures were negative, but eventually grew candida. This patient was a diabetic with a... candida fungal infection with stimulator
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
If you have diabetes, you know you're more prone to injury than the average patient. Foot ulcers are especially common for those with diabetes – and can unfortunately lead to hospitalization or infection. In fact, 14 to 24 percent of patients with diabetes who develop a foot ulcer will need an amputation, according to American Podiatric Medical Association. The reason foot ulcers tend to prey on diabetic patients is because the condition causes reduced circulation in the extremities, often leading to neuropathy. This lack of feeling makes it difficult for diabetic patients to recognize the pain before the sore be...
Source: Advanced Tissue - Category: Dermatology Authors: Tags: diabetic wound care Source Type: news
Conclusions: Our results can help direct health care professionals advice for women who are planning pregnancy towards walking as it seems to be sustained during pregnancy.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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