Does association of opioid use with pain and function differ by fibromyalgia or widespread pain status?

Abstract: Many consider chronic opioid therapy (COT) to be ineffective for fibromyalgia, but empirical evidence is limited. Among patients identified as initiating COT, we examined whether fibromyalgia was associated with different relationships of opioid use to pain and activity interference outcomes 12 months later. We obtained electronic data on diagnoses and opioid prescriptions. We obtained patient self-report data, including pain and activity interference measures, at baseline, 4 months, and 12 months. Among 1218 patients, 429 (35%) met our definition of fibromyalgia. Patients with and without fibromyalgia who had intermittent/lower-dose or regular/higher-dose opioid use at 12 months had similar 12-month pain intensity scores. However, among patients with minimal/no opioid use at 12 months, 12-month pain intensity was greater for those with fibromyalgia (adjusted mean = 5.15 [95% confidence interval, 4.80–5.51]; 0-10 scale) than for those without (4.44 [4.15–4.72]). Similar patterns were observed for 12-month activity interference. Among patients who discontinued opioids by 12 months, those with fibromyalgia were more likely to report bothersome side effects and less likely to report pain improvement as important reasons for discontinuation (P
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research

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Conditions:   Fibromyalgia Syndrome;   Fibromyalgia;   Pain, Chronic;   Impairment Intervention:   Other: Relaxometer Sponsor:   Azienda Ospedaliera Universitaria Integrata Verona Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsThe characteristic signs of a damaged thermo ‐nociceptive system as revealed by LEPs were absent in this large cohort of FMS patients.SignificanceThe present research does not support the hypothesis that small fibre neuropathy is a significant contributor to the pathophysiology of FMS.
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Publication date: Available online 9 November 2019Source: Journal of the Formosan Medical AssociationAuthor(s): Ke-Vin Chang, Chih-Hsien Hung, Wei-Zen Sun, Wei-Ting Wu, Chiu-Lian Lai, Der-Sheng Han, Chih-Cheng ChenBackgroundFibromyalgia is a chronic disorder characterized by widespread musculoskeletal pain. A common complaint is soreness. However, until now, no assessment tool is available to address soreness and evaluate its impact on disease severity. We aimed to establish a questionnaire for soreness assessment and to evaluate its validity in fibromyalgia patients.MethodsPatients diagnosed with fibromyalgia per the Amer...
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Abstract BACKGROUND: Fibromyalgia is a chronic disorder characterized by widespread musculoskeletal pain. A common complaint is soreness. However, until now, no assessment tool is available to address soreness and evaluate its impact on disease severity. We aimed to establish a questionnaire for soreness assessment and to evaluate its validity in fibromyalgia patients. METHODS: Patients diagnosed with fibromyalgia per the American College of Rheumatology criteria (2011) were recruited. The Revised Fibromyalgia Impact Questionnaire with an integration of Soreness Assessment (FIQRS) was established by adding fi...
Source: J Formos Med Assoc - Category: General Medicine Authors: Tags: J Formos Med Assoc Source Type: research
[Lysophosphatidic Acid Receptor Signaling Underlying Chronic Pain and Neuroprotective Mechanisms through Prothymosin α]. Yakugaku Zasshi. 2019;139(11):1403-1415 Authors: Ueda H Abstract For my Ph.D. research topic, I isolated endogenous morphine-like analgesic dipeptide, kyotorphin, which mediates Met-enkephalin release, and discovered kyotorphin synthetase, a putative receptor and antagonist. Furthermore, I succeeded in purifying μ-opioid receptor and functional reconstitution with purified G proteins. After receiving my full professor position at Nagasaki University in 1996, I worked on two...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
Abstract Currently, only a few medicines have been approved for use in the clinical treatment of chronic pain, but they are not fully satisfying due to their side effects. From the view that radical treatment, rather than simply treating symptoms, is more important in addressing life-long chronic pain, we have been investigating translational research for a mechanism-based medicine to treat pain. Through the characterization of various types of peripheral and central neuropathic pain in mice, we discovered that lysophosphatidic acid (LPA) plays roles in definitive mechanisms of the development and maintenance of n...
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Biol Pharm Bull Source Type: research
Publication date: June 2019Source: Best Practice &Research Clinical Rheumatology, Volume 33, Issue 3Author(s): Jon LampaAbstractChronic pain is a common symptom in rheumatic diseases, and the patient with pain and no signs of inflammation poses a challenge to the physician.Notably, all rheumatic diseases have components of non-inflammatory pain and a higher prevalence of fibromyalgia compared to the overall population.Hypothetically, a chronic pain stimulus may have stronger impact in a chronic inflammatory state, and the process towards a pain condition may be influenced by individual predisposition for development of...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
i Y Abstract Patients with fibromyalgia (FM) report high levels of sleep disturbance and chronic diffuse musculoskeletal pain. These patients experience diminished quality of life (QoL) due to pain and other comorbidities. Chronotype preferences have been suggested as a potential factor connecting increased severity of FM, sleep disturbances, and poor overall QoL. The present study is the first study examining the possible association between chronotype preferences, sleep disturbance, severity of FM, and QoL in patients with FM.One hundred drug-free patients diagnosed with FM participated in this cross-sectional s...
Source: Chronobiology International - Category: Biology Authors: Tags: Chronobiol Int Source Type: research
Eplingiella fruticosa (Lamiaceae) essential oil complexed with β-cyclodextrin improves its anti-hyperalgesic effect in a chronic widespread non-inflammatory muscle pain animal model. Food Chem Toxicol. 2019 Nov 03;:110940 Authors: John de Oliveira Melo A, Heimarth L, Maria Dos Santos Carvalho A, de Souza Siqueira Quintans J, Serafini MR, Antunes de Souza Araújo A, Alves PB, Ribeiro AM, Shanmugam S, Quintans-Júnior LJ, Duarte MC Abstract Eplingiella fruticosa (Lamiaceae), formally known as Hyptis fruticosa, is an important aromatic medicinal herb used in folk medicine in northeastern...
Source: Food and Chemical Toxicology - Category: Food Science Authors: Tags: Food Chem Toxicol Source Type: research
(Abstracted from Am J Obstet Gynecol 2019; doi: 10.1016/j.ajog.2019.06.044) Approximately 15% of women have chronic pelvic pain (CPP), which has a significant impact on quality of life and affects more than just the pelvis. Frequently, CPP is associated with irritable bowel syndrome, fibromyalgia, painful bladder syndrome, myofascial pain, and vulvodynia.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: GYNECOLOGY: OPERATIVE GYNECOLOGY Source Type: research
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