International Society for Heart & Lung Transplantation Reveals...

Sir Terence English Awarded Lifetime Achievement Award and James K. Kirklin MD Named as Distinguished Educator(PRWeb April 10, 2014)Read the full story at http://www.prweb.com/releases/2014/04/prweb11720796.htm
Source: PRWeb: Medical Pharmaceuticals - Category: Pharmaceuticals Source Type: news

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Abstract PURPOSE OF REVIEW: Owing to long waitlist times and high waitlist morbidity and mortality, strategies to increase utilization of hepatitis C viremic-deceased donor organs are under investigation in kidney, liver, heart, and lung transplantation. RECENT FINDINGS: Direct-acting antiviral medications for hepatitis C virus infection have high cure rates and are well tolerated. Small, single-center trials in kidney and heart transplant recipients have demonstrated that with early posttransplant direct-acting antiviral therapy, 100% of uninfected recipients of hepatitis C viremic organs have been cured of ...
Source: Current Opinion in Organ Transplantation - Category: Transplant Surgery Authors: Tags: Curr Opin Organ Transplant Source Type: research
Purpose of review Owing to long waitlist times and high waitlist morbidity and mortality, strategies to increase utilization of hepatitis C viremic-deceased donor organs are under investigation in kidney, liver, heart, and lung transplantation. Recent findings Direct-acting antiviral medications for hepatitis C virus infection have high cure rates and are well tolerated. Small, single-center trials in kidney and heart transplant recipients have demonstrated that with early posttransplant direct-acting antiviral therapy, 100% of uninfected recipients of hepatitis C viremic organs have been cured of infection after tran...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: ETHICAL CONSIDERATIONS OF ALLOCATION: Edited by David A. Axelrod Source Type: research
Increased shear stress conferred upon the circulation by continuous flow pumps is associated with hemocompatibility related adverse events, principally bleeding within the gastrointestinal system, and linked to degradation of high molecular weight multimers (HMWM) of von Willebrand factor (vWF). We evaluated the structure and functional characteristics of vWF HMWM in patients with the fully magnetically levitated centrifugal-flow HeartMate 3 (HM3) and the continuous axial-flow HeartMate II (HMII) pump.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
Authors: Chiriac A, Grosu OM, Terinte C, PerĊ£ea M Abstract Calciphylaxis is associated with end-stage renal failure or kidney transplant, although, cases of non-uremic calciphylaxis have been reported. It is a rare disorder, with high mortality, characterized by vascular calcification within cutaneous vessels; vascular calcification can occur in other organs, besides skin, like heart, lung or pancreas, which is named visceral calciphylaxis. The diagnosis is based mainly on clinical features and histopathological findings. Here, we review current knowledge regarding diagnosis and therapeutic approach to cutaneous c...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Dr Fardad Esmailian (Los Angeles, Calif). This is an important retrospective study of the UNOS database from 2006 to 2015 that demonstrates survival of the patients bridged to cardiac retransplantation with current contemporary MCS devices has significantly improved compared with previous studies. Furthermore, overall survival for patients requiring ECMO as a bridge to retransplantation continues to be poor, findings that are similar to previous studies with respect to primary cardiac transplantation and is confirmed by the International Society for Heart and Lung Transplantation registry.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
In this study, a significant (30%) increase in maximum lifespan of mice was found after nonablative transplantation of 100 million nucleated bone marrow (BM) cells from young donors, initiated at the age that is equivalent to 75 years for humans. Moreover, rejuvenation was accompanied by a high degree of BM chimerism for the nonablative approach. Six months after the transplantation, 28% of recipients' BM cells were of donor origin. The relatively high chimerism efficiency that we found is most likely due to the advanced age of our recipients having a depleted BM pool. In addition to the higher incorporation rates, ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
On April 13, 2019 we lost Michael L. Hess, MD to a 9-year battle with cancer.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Authors: Bolignano D, Pisano A, Arrigo GD Abstract Pulmonary hypertension (PH), an acknowledged risk condition at the community level and in patients with heart or lung diseases, is now getting growing attention as a new, potentially modifiable cardiovascular (CV) risk factor also in individuals affected by kidney diseases. PH is highly prevalent in this setting, being about 3 to 6 times more frequent that in the general population and portends a risk excess for mortality, adverse CV outcomes and also worsen graft function in kidney transplant recipients. Several factors might be involved to explain PH in renal pat...
Source: Reviews in Cardiovascular Medicine - Category: Cardiology Tags: Rev Cardiovasc Med Source Type: research
Abstract Finding a non-invasive biomarker to monitor allograft status after transplantation could contribute to better control of the post-transplant status of transplant recipients and, if possible, could be used instead of invasive biopsy for proving rejection. On the other hand, reducing the dosage of immunosuppression or stopping lifelong use of them because of their severe side effects is an important goal in order to dispose of their severe side effects. The ability of exosomes as a biomarker of rejection and as a therapeutic strategy was investigated in the human kidney, heart, and lung transplantation or i...
Source: Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Clin Immunol Source Type: research
Health care providers know the “eyeball test” well. It is not something you will find defined in any textbook or taught in any curriculum. Transplant providers know it in terms of evaluating a patient for transplant listing. Based on our interactions in clinic and in rehabilitation, we make an eyeball assessment of fitness fo r transplant. It feels haphazard and poorly defined. In a world where donors are limited and prospective recipients are increasing in age and comorbidity burden, the transplant community needs better tools to make the difficult decision of who to list for transplant.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Editorial Source Type: research
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