Accuray touts 5-year CyberKnife data in prostate cancer trial

Accuray (NSDQ:ARAY) today released 5-year data from a study of its CyberKnife stereotactic body radiotherapy device for treating prostate cancer, touting a 97% rate of freedom from cancer after treatment at 5-years. Results from the study were presented at the American Society for Therapeutic Radiology and Oncology’s annual meeting in Boston. The 21-site, 309-patient trial looked to examine whether dose-escalated SBRT can be administered across multiple institutions without grade 3+ toxicities exceeding 10%. The study followed patients for 5 years and reported toxicity, survival and relapse-free survival outcomes. At 5 years, overall survival was 95.6%, with a 97.1% rate of relapse-free survival for all patients, as rated by nadir+ definitions. 5 year ASTRO consensus RFS was 92.3% for low risk groups and 91.3% for intermediate-risk groups. A total of 5 grade 3+ toxicities were reported at 1.6%, well below the 10% rate deemed “excessive”, and no grade 4 or 5 toxicities were reported. Five patients developed urinary intervention which required temporary catheter placement, and 7 patients were diagnosed with bladder cancer between 21 and 50 months, according to the study. “With appropriate treatment delivery and constraints, dose-escalated prostate SBRT can be safely administered across multiple institutions. Toxicity rates and RFS rates compare favorably to other radiotherapies. SBRT appears to be a suitable option for low- and intermediate-risk pro...
Source: Mass Device - Category: Medical Equipment Authors: Tags: Clinical Trials Oncology Radiosurgery Accuray Inc. Source Type: news

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POP-RT trial by Murthy, et al [1] addresses the impact of addition of elective pelvic irradiation (WPRT) in node negative locally advanced prostate cancer (PC). Although the primary endpoint of biochemical progression free survival has not been reported yet, the study showed that there is a significant increase in late grade 2+ genitourinary (GU) toxicity in patients who received WPRT. The authors noted that this corresponded to irradiation of urinary bladder (UB) to doses between 30-50Gy. We congratulate the authors for this important study and would like to present the following observations:
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Letter to the Editor Source Type: research
Conclusion: We report the efficacy and safety of IFX maintained for up to 12 years in psoriasis patients. The long-term use of IFX was associated with a high BMI confirming the critical role of weight-based dosing for this drug. PMID: 32231699 [PubMed]
Source: Dermatology Research and Practice - Category: Dermatology Tags: Dermatol Res Pract Source Type: research
CONCLUSIONS: The mean QALY gained from surgical decompression in the first 6 months and first year equals 1.2 months and 5 months of life in perfect health, respectively. These findings suggest that surgery might also be beneficial to patients with life expectancy
Source: Journal of Neurosurgery.Spine - Category: Neurosurgery Authors: Tags: J Neurosurg Spine Source Type: research
Purpose of review Patients with nonmuscle invasive bladder cancer (NMIBC) have a high risk of recurrent tumors, even in spite of contemporary guideline recommended therapy. Follow-up recommendations are also clear (cystoscopy with cytology and upper urinary tract imaging in high-risk patients), but frequency and duration of follow-up are well defined. However, recent developments in follow-up tools might be of interest for clinical practice. Recent findings Enhanced endoscopy improves detection and treatment of recurrences, and it can help in tailoring follow-up. However, it remains an invasive procedure. Most recentl...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: BLADDER CANCER: Edited by Juan Palou and Óscar Rodríguez Faba Source Type: research
The Florida Legislature has passed a bill designed to better protect its firefighters from cancer-causing contaminants, including toxic asbestos. By approving the legislation, Florida joined a growing number of states that have passed laws in recent years to help firefighters combat occupational hazards they face every day. The Firefighter Cancer Decontamination Equipment Grant Program in Florida will provide funding for departments to procure supplies, equipment and add additional training that should reduce exposure to hazardous pollutants. It includes all fire departments across the state, from large municipal entities...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
CONCLUSION: Spatial agreement between methods is relatively good although DVM identified more sub-regions. Reproducibility of identified Ssurf between cohorts is low. PMID: 32224316 [PubMed - as supplied by publisher]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
Abstract INTRODUCTION: Compared to low-volume hospitals, high-volume hospitals are associated with lower rates of perioperative morbidity and mortality. However, access to high-volume hospitals is unequal. We investigated racial and socioeconomic disparities among patients undergoing surgery for genitourinary malignancies at high-volume hospitals. MATERIAL AND METHODS: We queried the National Cancer Database from 2004-2015 to identify patients who underwent radical prostatectomy, radical cystectomy, and nephrectomy for nonmetastatic prostate cancer, muscle-invasive urothelial bladder cancer, and kidney cancer...
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research
Abstract BACKGROUND: Hepatocellular carcinoma (HCC) recurrence and development of de novo malignancy (DNM) after liver transplantation (LT) are the major causes of late recipient death. METHODS: We analyzed the incidence of extrahepatic DNM following living donor LT according to the status of pretransplant hepatic malignancy. We selected 2,076 adult patients who underwent primary LDLT during 7 years from January 2010 to December 2016. RESULTS: The pretransplant hepatic malignancy group (n = 1,012) showed 45 cases (4.4%) of the following extrahepatic DNMs: posttransplant lymphoproliferative disease (PTLD)...
Source: J Korean Med Sci - Category: General Medicine Authors: Tags: J Korean Med Sci Source Type: research
Publication date: Available online 19 March 2020Source: Meta GeneAuthor(s): Yaroslava Mishchuk, Yevhenia Kharkivska, Svitlana Serga, Eduard Stakhovskyi, Oleksandr Stakhovskyi, Oleksii Kononenko, Oleksandr Koliada, Olga Ponomarova, Roman Gulkovskyi, Liudmyla Ostapchenko, Sergii Demidov, Iryna Kozeretska
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
CONCLUSIONS: The NAKO is a rich data basis for future investigations of incident cancer. PMID: 32179962 [PubMed - as supplied by publisher]
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - Category: International Medicine & Public Health Authors: Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research
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