Levodopa Effect on Basal Ganglia Motor Circuit in Parkinson's Disease.

CONCLUSION: In PD patients with asymmetrical bradykinesia, levodopa can partially normalize the connectivity of the BGMC with a larger effect on the more severely affected side. Moreover, the beneficial effect of levodopa on bradykinesia is associated with normalization of the striato-thalamo-cortical motor and STN-cortical motor pathways. Our findings inform the neural mechanism of levodopa treatment in PD. PMID: 27663605 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/27663605?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - September 23, 2016 Category: Neuroscience Authors: Gao LL, Zhang J, Chan P, Wu T Tags: CNS Neurosci Ther Source Type: research