Transient vascular and long-term alveolar deficits following a hyperoxic injury to neonatal mouse lung

Conclusions: This study suggests that administration of high oxygen to underdeveloped lungs has a transient reductive effect on secondary septal number and pulmonary vascularization and a significant long-term reduction in alveolarization persisting into adulthood. This model can be used for future research of premature lung disease therapies in humans, addressing these short term septal and vascular and long term alveolar deficits, specifically relating to injury by hyperoxia.
Source: BMC Pulmonary Medicine - Latest articles - Category: Respiratory Medicine Authors: Source Type: research