What 1989 And The Golden Girls Tell Us About Medicine Today
Today, 1989 may be most associated with Taylor Swift: It is the album that won her a second Grammy for Album of the Year. Not only that, it happens to be the year Swift was born--such a long, long time ago! People under 35 have no personal memory of 1980s pop culture, which is ironic since Swift's album in part pays homage to it. In the real 1989 (no offense to Swift and the 10 co-producers who made the album), all sorts of revolutions took place: Mr. Gorbachev tore down that pesky wall, for example. America's greatest antagonist, the Soviet Union, collapsed in 1989. Brazil conducted its first democratic presidential election since 1960. And so on. Today, it's hard to say whether America's greatest existential threat may be Vladimir Putin or his Number-One American Fan, Donald Trump. If the CDC is to be believed, it's the Zika virus. Two years ago (2014, the year Swift's 1989 came out), the CDC was most concerned about Ebola, to the extent that the U.S. public health agency was criticized for "roughing up" humanitarian aid workers who had helped to treat those with Ebola who were suffering abroad. Way back in the early 80s, the CDC was criticized for doing too little about the emerging and little-understood AIDS crisis: Specifically, in 1982, the CDC cautioned the public that four groups of people had to worry about developing AIDS: homosexual or bisexual men, IV drug users, people with hemophilia, and Haitian people. (There wa...
In conclusion, BLU-5937 was selected as a drug candidate for the treatment of chronic cough due to its high potency and selectivity for P2X3 homotrimeric receptors, strong anti-tussive effects, excellent tolerability and predicted pharmacokinetic properties in humans.
ConclusionsThese findings indicate that the neural effects of AUD vary according to severity. Our results emphasize the utility of resting state fMRI as a neuroimaging biomarker for quantitative clinical evaluation of AUD.
Publication date: August 2019Source: Current Opinion in Behavioral Sciences, Volume 28Author(s): Bianka Karshikoff, Melissa Anne Tadros, Sean Mackey, Ihssane ZouikrToday’s treatment for chronic pain is inadequate, and novel targets need to be identified. This requires a better understanding of the mechanisms involved in pain sensitization and chronification. In this review, we discuss how peripheral inflammation, as occurs during an infection, modulates the central pain system. In rodents, neonatal inflammation leads to increased pain sensitivity in adulthood by priming immune components both peripherally and central...
Conclusions: A critical examination of the results of each study suggests that NA helps to identify, in an innovative way, important aspects of psychopathology like the centrality of the symptoms in a given disorder as well as the mutual dynamics among symptoms. Yet, despite these promising results, the clinical utility of NA is still uncertain as there are important limitations on the analytic procedures (e.g., reliability of indices), the type of data included (e.g., typically restricted to secondary analysis of already published data), and ultimately, the psychometric and clinical validity of the results.Psychother Psychosom
ConclusionsFOSL1 is an independent prognostic biomarker of GC. Detecting FOSL1 expression could help stratify GC patients with high-risk and guide the precious treatment.
In this study, we aimed to investigate the role of IL-6/Stat3 signaling pathway in human endometrial cancer cells invasion and migration. We demonstrated that Stat3 is activated in endometrial cancer cell lines. To investigate the role of Stat3 in endometrial cancer invasive capacity, we used Stat3 inhibitor Stattic and found that Stattic significantly inhibited the migration and invasion of endometrial cancer cells elevated by IL-6. Furthermore, we showed that Stat3 inhibitor significantly decreased the expression of MMP2 enhanced by IL-6, indicating that IL-6 promoted endometrial cancer invasion and migration by Stat3-in...
Publication date: Available online 19 March 2019Source: Pathology - Research and PracticeAuthor(s): Xiaobo He, Ying ShuAbstractIncreasing evidence has shown that dysregulation of mircoRNA (miRNA) is linked to the development and progression of human cancer, including gastric cancer (GC). In the current study, by analysing the GEO database (GSE78091), we found that miR-660 was significantly downregulated in GC. Consistently, quantitative real-time PCR (qRT-PCR) results showed that miR-660 was dramatically decreased in GC tissues and cell lines. Importantly, low miR-660 expression was closely related to larger tumor size (P&...
ConclusionsThe results pointed out that the high expression of miR-106b-5p serves as an independent factor for predicting the worse prognosis of RCC patients.
Publication date: Available online 20 March 2019Source: The Journal of Foot and Ankle SurgeryAuthor(s): J. Randolph Clements, Ajay K. GhaiAbstractDisruption of the plantar plate is a common cause of forefoot pain, metatarsalgia, and metatarsophalangeal joint malalignment. Although surgical repair of the plantar plate has improved, there has been no consensus on the clinical superiority of any single technique, or combination of techniques, described in the literature to date. In this publication, we report a case of plantar plate injury treated with an innovative new technique with 20-month follow-up.
Publication date: Available online 20 March 2019Source: Orthopaedics &Traumatology: Surgery &ResearchAuthor(s): Jean-Yves Jenny, Michel Bonnin, Didier Mainard, French Society of Hip and Knee Surgery (SFHG), French Society of Orthopedic Surgery and Traumatology (CNP-SoFCOT)
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