Paracrine nitric oxide induces expression of cardiac sarcomeric proteins in adult progenitor cells through soluble guanylyl cyclase/cyclic-guanosine monophosphate and Wnt/{beta}-catenin inhibition

Conclusions Exogenous or paracrine sources of NO promote the specification towards the myocyte lineage and expression of cardiac sarcomeric proteins of adult CPC. This is contingent upon the expression and activity of the alpha1 subunit of guanylyl cyclase in CPC that is necessary for NO-mediated inhibition of the canonical Wnt/β-catenin pathway.

http://cardiovascres.oxfordjournals.org/cgi/content/short/112/1/478?rss=1

Source: Cardiovascular Research - September 21, 2016 Category: Cardiology Authors: De Pauw, A., Massion, P., Sekkali, B., Andre, E., Dubroca, C., Kmecova, J., Bouzin, C., Friart, A., Sibille, C., Gilon, P., De Mulder, D., Esfahani, H., Strapart, A., Martherus, R., Payen, V., Sonveaux, P., Brouckaert, P., Janssens, S., Balligand, J.-L. Tags: Cardiac biology and remodelling Source Type: research