Chronic myelogenous leukemia with acquired t(11;14)(q13;q32) CCND1-IGH: a case report and literature review

• This is an unique case of CML in chronic phase with both the Philadelphia chromosome as well as t(11;14) at initial diagnosis.• Translocation t(11;14)(q13;q32) CCND1-IGH is typically associated with mantle cell lymphoma or a subset of plasma cell myeloma and is exceedingly rare in myeloid neop lasm.• Most likely, the Philadelphia chromosome is the primary cytogenetic abnormality also called the “driver” mutation and the t(11;14)(q13;q32) the secondary or “passenger” mutation in this case. Upregulated cyclin D1 may further promote cells go into cell cycle, thus it may render high er proliferation of the disease as well as resistance to BCR-ABL targeted therapy.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research