Risk of acute anastomotic leakage after preoperative radiotherapy in rectal cancer

Conclusions Radiotherapy may affect anastomotic healing and increase the risk of leakage. This risk is higher in low anterior anastomoses where a protective stoma may be considered. A better evaluation and support for patients with preoperative radiotherapy is needed in order to diminish the concomitant risk factors as much as possible.
Source: Journal of Acute Disease - Category: Emergency Medicine Source Type: research

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Authors: Takeuchi N, Koike K, Yoshida S, Fujiwara M Abstract Recent therapeutic advancements have prolonged the survival duration of patients with metastatic or recurrent colorectal cancer even during salvage treatment. Although treatment with regorafenib and trifluridine/tipiracil combination has exhibited apparent survival benefits, clear and objective evidence of a response to these drugs is scarce. Herein, the present study reports the case of a patient with rectal cancer refractory to multiple surgical interventions and standard chemotherapy. Treatment with regorafenib resulted in immediate improvement of resp...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
This study inv...
Source: World Journal of Surgical Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
ConclusionIFs not related to prostate cancer may be frequently encountered on multiparametric prostate MRI, and they are significantly more common in patients  >  65 years old.
Source: La Radiologia Medica - Category: Radiology Source Type: research
ConclusionIn accordance with the literature, we confirmed that RC is significantly associated with fecal and urinary incontinence. However, it appears that the awareness of this fact needs to be improved among general practitioners since our data show lower percentages of fecal and urinary incontinence diagnoses compared with the percentages for specialized centers reported in the literature.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
ConclusionsNetwork pharmacology analysis revealed that the compounds isoquercitrin, quercitrin, berberine, chlorogenic acid and caffeic acid showed strong synergistic interactions with the cancer-related targets and pathways. It could be concluded that N. domestica Thunb. constituents affect both apoptosis and Akt-signaling pathways during the stages of early and intermediate adenoma through interaction with the targets CASP3 and MAPK1 (ErC2) while during the stages of late adenoma and carcinoma, the compounds acts through the p53 and ErbB signaling pathways.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Wang L, Yang L, Yang J, Shan S Abstract Background: Permissive hypercapnia has been recommended during the treatment of chronic diseases; however, there are insufficient clinical data to investigate the feasibility of permissive hypercapnia in relatively long-term surgeries such as laparoscopic surgery for rectal carcinoma. This prospective study is aimed at investigating the efficacy and safety of permissive hypercapnia under different CO2 pneumoperitoneum pressures during the laparoscopic surgery for rectal carcinoma. Methods: A total of 90 patients undergoing laparoscopic surgery for rectal carcinom...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Conditions:   Rectal Neoplasms Malignant;   Rectum Carcinoma;   Rectal Cancer Interventions:   Drug: Capecitabine;   Drug: Oxaliplatin;   Radiation: Radiotherapy;   Procedure: Rectal cancer surgery Sponsor:   Blokhin's Russian Cancer Research Center Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Rectal Neoplasms Malignant;   Rectum Carcinoma;   Rectal Cancer Interventions:   Drug: Capecitabine;   Drug: Oxaliplatin;   Radiation: Radiotherapy;   Procedure: Rectal cancer surgery Sponsor:   Blokhin's Russian Cancer Research Center Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Rectal Neoplasms Malignant;   Rectum Carcinoma;   Rectal Cancer Interventions:   Drug: Capecitabine;   Drug: Oxaliplatin;   Radiation: Radiotherapy;   Procedure: Rectal cancer surgery Sponsor:   Blokhin's Russian Cancer Research Center Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Rectal Neoplasms Malignant;   Rectum Carcinoma;   Rectal Cancer Interventions:   Drug: Capecitabine;   Drug: Oxaliplatin;   Radiation: Radiotherapy;   Procedure: Rectal cancer surgery Sponsor:   Blokhin's Russian Cancer Research Center Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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