Recent advances on acute paraplegia

Publication date: Available online 20 September 2016 Source:Journal of Acute Disease Author(s): Gentian Vyshka, Dritan Muzha, Meri Papajani, Maksim Basho Paraplegia and spinal cord injuries are issues of major concern to the actual medicine. But recent advances have raised hopes for a better prognosis, which has always been poor or infaust since medicine was practiced. However and interestingly enough, some concepts and definitions on the occurrence have survived for millennia. Once encountered as an issue, traumatic or non-traumatic paraplegia needs a multidisciplinary approach and a careful staging of the problem. Different scales are available with Frankel’s and American Spinal Injury Association most widely used as alternatives or complementary tools. The authors discuss therapeutic options with a special focus on the stem cell therapy which has seen an impressive increase on the number of trials for a successful treatment. Sourcing and yielding of stem cells are made possible through a number of techniques, with material aspirated from bone marrow or adipose tissue, which are used along with other sources of neuronal precursors such as olfactory ensheathing cells. Nervertheless, large and multicenter studies are still lacking. However, with the quality of the ongoing work and research, the optimistic attitude seems warranted. Meanwhile, other rehabilitation and medical care interventions, always at hand, need to be applied in every individual suffering from parapl...
Source: Journal of Acute Disease - Category: Emergency Medicine Source Type: research

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Authors: Jeong SK, Choi I, Jeon SR Abstract Spinal cord injury (SCI) is one of the most devastating conditions and many SCI patients suffer neurological sequelae. Stem cell therapies are expected to be beneficial for many patients with central nervous system injuries, including SCI. Adult stem cells (ASCs) are not associated with the risks which embryonic stem cells have such as malignant transformation, or ethical problems, and can be obtained relatively easily. Consequently, many researchers are currently studying the effects of ASCs in clinical trials. The environment of transplanted cells applied in the injured...
Source: Journal of Korean Neurosurgical Society - Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research
Great for use a controls vs Differentiated iPSCsWe have a cornucopia ofHuman Primary Neuron, Astrocytes and Schwann Cells plus CAFS. Featured Assays:Human Brain Pericytes used to study Guide Axon Guidance.Human Pancreatic CAFS and Tumor Dynamics.Axon guidance at the site of a cervical spinal cord injury in a rat model. (Ai) Schematic illustrating transplantation of scaffold into a C-4 hemisection. The injury cavity is shown prior to (ii) and immediately following (iii) transplantation. (Bi) Scaffold conditioned with flow exhibits viable GFP-labeled microvessels (green) (ii) and alignment of host axons (magenta) infiltratin...
Source: Neuromics - Category: Neuroscience Tags: adult stem cells CAFs Cancer Associated Fibroblasts human Astrocytes Human Endothelial Cells Human Neurons Primary Human Neurons Source Type: news
CONCLUSIONS: Significant motor neurological recovery and AIS-grade promotion was observed in Group-1 as compared to Group-2 and 3.
Source: Asian Journal of Transfusion Science - Category: Hematology Authors: Source Type: research
Early research published in Mayo Clinic Proceedings examines the first case at Mayo Clinic of stem cell therapy tested in humans for spinal cord injury. The case study found stem cell intervention, which took place after standard surgery, and physical and occupational therapy, restored some function in a patient with spinal cord injury. The report, [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news
AbstractRegenerative medicine is a branch of translational research that aims to reestablish irreparably damaged tissues and organs by stimulating the body ’s own repair mechanismsvia the implantation of stem cells differentiated into specialized cell types. A rich source of adult stem cells is located inside the tooth and is represented by human dental pulp stem cells, or hDPSCs. These cells are characterized by a high proliferative rate, have self-renewal and multi-lineage differentiation properties and are often used for tissue engineering and regenerative medicine. The present review will provide an overview of h...
Source: Cell and Tissue Research - Category: Cytology Source Type: research
ROCHESTER, Minn. -- Stem cells derived from a patient's own fat offer a step toward improving -- not just stabilizing -- motor and sensory function of people with spinal cord injuries, according to early research from Mayo Clinic. A clinical trial enrolled 10 adults to treat paralysis from traumatic spinal cord injury. After stem cell [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news
Spinal cord injury (SCI) is a devastating condition with limited pharmacological treatment options to restore function. Regenerative approaches have recently attracted interest as an adjuvant to current standard of care. Adipose tissue –derived (AD) mesenchymal stem cells (MSCs) represent a readily accessible cell source with high proliferative capacity. The CELLTOP study, an ongoing multidisciplinary phase 1 clinical trial conducted at Mayo Clinic (ClinicalTrials.gov Identifier: NCT03308565), is investigating the safety and eff icacy of intrathecal autologous AD-MSCs in patients with blunt, traumatic SCI.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Case report Source Type: research
In this study, we reviewed the current progress of the studies on the involvement of lncRNAs in SCI, with the aim of drawing attention towards their roles in this debilitating condition. PMID: 31737660 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
This study investigated the therapeutic effects of human breast milk stem cell (BMSC)-conditioned medium (BMSC-CM) in a model of spinal cord injury (SCI) in male Sprague-Dawley rats. Overview of Literature: SCI is one of the leading causes of disability in addition to sensory and motor impairment. So far, there have been no successful treatments for SCI. Given the positive outcomes associated with using stem cells and their derivatives as a treatment for various diseases, there is a growing interest in using them as an SCI treatment. Recent research has demonstrated that CM from stem cells has therapeutic advantages. ...
Source: Asian Spine Journal - Category: Orthopaedics Tags: Asian Spine J Source Type: research
Stem cells hold a great deal of promise in treating a huge variety of human diseases. Although much hyped to the general public some years ago, it turned out to be very difficult to safely use stem cells to generate replacement tissues without inadve...
Source: Medgadget - Category: Medical Devices Authors: Tags: Materials News Pathology Source Type: blogs
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