Genetic, Maternal, and Environmental Risk Factors for Cryptorchidism: An Update

Eur J Pediatr Surg DOI: 10.1055/s-0036-1592416Unilateral or bilateral cryptorchidism is an isolated anomaly in the majority of cases, with evidence to date suggesting that it is a complex disorder resulting from interactions between genetic and environmental factors. Population, family, and limited genome-wide association data suggest moderate genetic risk, multiple susceptibility loci, and a role for the maternal environment. Epidemiologic studies have identified low birth weight or intrauterine growth retardation as factors most strongly associated with cryptorchidism, with additional evidence suggesting that maternal smoking and gestational diabetes increase risk. Animal studies have shown that the testis regulates its own descent by secretion of hormones that stimulate differentiation of the gubernaculum, and that endocrine-disrupting chemicals (EDCs) exhibit antiandrogenic and/or estrogenic activity that alters testicular function or gubernacular response to hormonal stimulation. However, we have yet to determine the degree to which EDCs contribute to cryptorchidism risk in humans, in part due to the varying methodology used in epidemiological and exposure studies. Large populations will be required to define the gene–environment interactions that predispose to cryptorchidism, in view of multiple small effect genetic susceptibility loci, ubiquitous exposure to mixtures of EDCs, and possible epigenetic effects. The present review provides an update of potential gene...
Source: European Journal of Pediatric Surgery - Category: Surgery Authors: Tags: Review Article Source Type: research

Related Links:

CONCLUSION: According to the high percentage of patients diagnosed with vision-threatening DR in this study, an early diagnosis of this complication of diabetes seems to be important. Teleophthalmology enhances patient accessibility to the healthcare system, making early diagnosis of DR easier, with a high degree of satisfaction among patients and healthcare professionals. PMID: 31941342 [PubMed - in process]
Source: Rural and Remote Health - Category: Rural Health Tags: Rural Remote Health Source Type: research
Bigfoot Gets by with a Little Help from Its Friends Bigfoot Biomedical is on track to submit its diabetes technology for FDA clearance this year, and the product could hit the market by year end. It helps that the company has some friends with deep pockets like Abbott and other investors that kicked in a total of $45 million in an initial tranche of a series C financing. Bigfoot's injection-based digitized insulin dosing platform uses a connected insulin pen-based system that integrates Abbott’s FreeStyle Libre glucose sensing technology.   DexCom Gives JPM ...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news
ConclusionBerberine could impede the development of dementia via multiple mechanisms: preventing brain damages and enhancing cognition directly in the brain, and indirectly through alleviating risk factors such as metabolic dysfunction, and cardiovascular, kidney and liver diseases. This study provided evidence to support the value of berberine in the prevention of dementia associated with MetS.
Source: Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Diabetic peripheral neuropathy (DPN) is a common chronic complication of diabetes mellitus. It leads to distressing and expensive clinical sequelae such as foot ulceration, leg amputation, and neuropathic pain (painful-DPN). Unfortunately, DPN is often diagnosed late when irreversible nerve injury has occurred and its first presentation may be with a diabetic foot ulcer. Several novel diagnostic techniques are available which may supplement clinical assessment and aid the early detection of DPN. Moreover, treatments for DPN and painful-DPN are limited. Only tight glucose control in type 1 diabetes has robust evidence in re...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Renza Scibilia, manager of type 1 diabetes and consumer voice at Diabetes Australia, says diabetes is a data-driven health condition and those with the disease should be provided choices of treatment plans and supported in their choices.
Source: Healthcare ITNews Videos - Category: Information Technology Tags: Patient Engagement Population Health Women In Health IT Source Type: video
Conclusion: Administration of CoQ10 for 3 months in T1DM pediatric patients was well tolerated but had no favorable effect on ED or metabolic parameters. PMID: 31942840 [PubMed - as supplied by publisher]
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
Conclusions: PEG-HCC can improve some parameters of disease in these models and this may be due to a resulting increase in peripheral insulin sensitivity. However, additional studies are needed to elucidate how PEG-HCCs are producing these effects. PMID: 31937152 [PubMed - as supplied by publisher]
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
Decline in all - cause mortality from 2001 to 2016 not statistically significant for those aged 20 to 44 years
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Cardiology, Endocrinology, Family Medicine, Gynecology, Internal Medicine, Nursing, Oncology, Journal, Source Type: news
CONCLUSION: It is very important for public health that the current EU standards for rkedly lowered so that health risks can be further reduced, in accordance with the recommendations of the WHO. PMID: 31941576 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
We report a case of rhinofacial mucormycosis in a 39-year-old diabetic patient. The diagnosis was established by clinical examination, imaging, and confirmed by mycological examination. Rhizopus arrhizus was isolated. He was successfully treated with amphotericin B, surgical resection, diabetes control and hyperbaric oxygen therapy.
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
More News: Chemistry | Diabetes | Endocrinology | Environmental Health | Epidemiology | Genetics | Hormones | Pediatrics | Smokers | Study | Surgery