+5 | The top 5 medtech stories for September 19, 2016

Say hello to MassDevice +5, a bite-sized view of the top five medtech stories of the day. This feature of’s coverage highlights our 5 biggest and most influential stories from the day’s news to make sure you’re up to date on the headlines that continue to shape the medical device industry. Get this in your inbox everyday by subscribing to our newsletters.   5. Edwards Lifesciences wins expanded CE Mark for Sapien 3 replacement heart valve Edwards Lifesciences said today that it won CE Mark approval in the European Union for an expanded indication for its Sapien 3 transcatheter aortic valve replacement. The expanded indication covers patients at intermediate risk for open heart surgery, Irvine, Calif.-based Edwards said. Last month the FDA also expanded the Sapien 3 indication to include intermediate-risk aortic stenosis patients. The device won its original CE Mark approval back in January 2014, with the U.S. federal safety watchdog following suit in June 2015. Read more 4. Gore launches trial for Tag thoracic branch endoprosthesis W.L. Gore &Assoc. said today that it enrolled the 1st patient in a pivotal study evaluating its Tag thoracic branch endoprosthesis as a treatment for lesions of the aortic branch and descending thoracic aorta. The Tag TBE is the 1st Gore device to win the FDA’s expedited access pathway designation and among the 1st medical devices in the U.S. to do so, the Phoenix-based company reported. It&...
Source: Mass Device - Category: Medical Equipment Authors: Tags: News Well Plus 5 Source Type: news

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In this study, proteomics was used to characterize sites of covalent protein-protein crosslinking and identify a novel mechanism of protein-protein crosslinking in the adult human lens. In this mechanism, Lys residues are crosslinked to C-terminal Asp residues that are formed by non-enzymatic protein truncation. Ten different crosslinks were identified in lens major proteins such as αA-crystallin, αB-crystallin and AQP0. Crosslinking in AQP0 increased significantly with age and also increased significantly in cataract lenses compared with normal lenses. Using model peptides, a mechanism of formation of the Lys-...
Source: Biochimica et Biophysica Acta (BBA) Proteins and Proteomics - Category: Biochemistry Source Type: research
Publication date: Available online 19 June 2019Source: Journal of Health EconomicsAuthor(s): Luís Sá, Luigi Siciliani, Odd Rune StraumeAbstractWe develop a dynamic model of hospital competition where (i) waiting times increase if demand exceeds supply; (ii) patients choose a hospital based in part on waiting times; and (iii) hospitals incur waiting time penalties. We show that, whereas policies based on penalties will lead to lower waiting times, policies that promote patient choice will instead lead to higher waiting times. These results are robust to different game-theoretic solution concepts, designs of th...
Source: Journal of Health Economics - Category: Health Management Source Type: research
(Concordia University) Using high-tech equipment to look at the flow downstream of a bi-leaflet mechanical heart valve, researchers at Concordia have devised a technique to detect obstructions in a type of mechanical heart valve they believe will contribute to safer follow-up methods for cardiologists and their patients.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
CONCLUSIONS: The varied pharmacologic mechanisms of NBP involve many complex molecular mechanisms; however, there many unknown pharmacologic effects await further study. PMID: 31205106 [PubMed - in process]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print
Source: Clinical Chemistry and Laboratory Medicine - Category: Laboratory Medicine Source Type: research
  Americans consume the equivalent of 300 loaves of bread each year (representing enormous exposure to the amylopectin A carbohydrate that behaves like sugar or worse). They also consume 200 pounds of sugar. It is not uncommon for sugar alone to comprise a quarter of all calories taken in over the course of the day—some of it out in the open, some of it hidden. To understand the adverse effects of sugars—sucrose, high-fructose corn syrup, and other fructose-rich sweeteners, such as agave, honey, and maple syrup—we need to understand two phenomena: 1. Insulin resistance 2 Glycation. Insulin Resistanc...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Anti-aging BLOOD SUGAR Diabetes Dr. Davis Undoctored arthritis dementia grain-free grains health heart disease insulin joint pain weight gain Weight Loss wheat belly Source Type: blogs
Conclusions: Our case series underscores the efficacy of ASA at relieving LVOT obstruction and improving symptoms in properly selected HOCM patients, with acceptably low procedural and long term mortality and morbidity. PMID: 31204591 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
Authors: Kakizaki R, Meguro K, Kitamura T, Hashimoto T, Ako J Abstract A 92-year-old man with acute heart failure due to severe aortic stenosis underwent transcatheter aortic valve implantation (TAVI). Computed tomography demonstrated severe stenosis of the right common iliac artery, occlusion of the left external iliac artery, and stenosis of the left subclavian artery. Severe calcification was observed in the sinotubular junction, which was considered a risk factor for aortic dissection with transapical TAVI using a balloon-expanding bioprosthetic valve. Therefore, transaortic (TAo) access was the only option for...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
This cohort study uses registry data to describe trends and incidence of 30-day stroke among patients who had undergone transcatheter aortic valve replacement (TAVR) in the first 5 years the procedure ’s use in US clinical practice.
Source: JAMA - Category: General Medicine Source Type: research
This study reported about a 7% risk of stroke, which was not surprising given the patient population and the likelihood of particulate embolization when expanding a new valve within the annulus of the stenosed and calcified native valve. Nevertheless, even with this stroke risk, there was a clear mortality benefit and quality of life was improved as well. After the PARTNER 1A high-risk cohort demonstrated similar or improved outcomes relative to open surgical aortic valve replacement (SAVR) in patients at high (but not inoperable) surgical risk, the US Food and Drug Administration (FDA) approved TAVR in 2011 and the proced...
Source: JAMA - Category: General Medicine Source Type: research
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