Characteristics of histologically confirmed endometriosis in cynomolgus monkeys
STUDY QUESTION
What are the characteristics of spontaneous endometriosis in cynomolgus monkeys?
SUMMARY ANSWER
Spontaneous endometriosis in cynomolgus monkeys exhibited similar characteristics to the human disease.
WHAT IS KNOWN ALREADY
One previous report described the prevalence and the basic histopathology of spontaneous endometriosis in cynomolgus monkeys.
STUDY DESIGN, SIZE, DURATION
Endometriotic lesions that had been histologically confirmed in 8 female cynomolgus monkeys between 5 and 21 years old were subjected to study.
PARTICIPANTS/MATERIALS, SETTING, METHODS
The monkeys died of, or were sacrificed because of, sickness consequent on endometriosis. Specimens were evaluated histopathologically with haematoxylin and eosin staining, iron staining and immunohistochemistry (CD10, CD31, α-SMA and PGP9.5), and by observing them under a microscope.
MAIN RESULTS AND THE ROLE OF CHANCE
Endometriotic and stromal cells (CD10-positive) with haemorrhage and inflammation were observed. Smooth muscle metaplasia and nerve fibres were also noted in the endometriotic lesions. Endometriotic lesions in lymph nodes were incidentally found.
LIMITATIONS AND REASONS FOR CAUTION
Since laparoscopic analysis for monitoring the disease state was not set as a parameter of the current study, time course changes (progression) of the disease were not assessed.
WIDER IMPLICATIONS OF THE FINDINGS
Further investigation of spontaneous endometriosis in cynomolgus monkeys may contribute to b...
Source: Human Reproduction - Category: Reproduction Medicine Authors: Nishimoto-Kakiuchi, A., Netsu, S., Matsuo, S., Hayashi, S., Ito, T., Okabayashi, S., Yasmin, L., Yuzawa, K., Kondoh, O., Kato, A., Suzuki, M., Konno, R., Sankai, T. Tags: Reproductive biology Source Type: research