Influence of embryo culture medium (G5 and HTF) on pregnancy and perinatal outcome after IVF: a multicenter RCT

This study was powered to detect a 10% difference in live births while a smaller difference could still be clinically relevant. The effect of other culture media on perinatal outcome remains to be determined. WIDER IMPLICATIONS OF THE FINDINGS Embryo culture media used in IVF affect not only treatment efficacy but also perinatal outcome. This suggests that the millions of human embryos that are cultured in vitro each year are sensitive to their environment. These findings should lead to increased awareness, mechanistic studies and legislative adaptations to protect IVF offspring during the first few days of their existence. STUDY FUNDING/COMPETING INTEREST(S) This project was partly funded by The NutsOhra foundation (Grant 1203-061) and March of Dimes (Grant 6-FY13-153). The authors declare no conflict of interest. TRIAL REGISTRATION NUMBER NTR1979 (Netherlands Trial Registry). TRIAL REGISTRATION DATE 1 September 2009. DATE OF FIRST PATIENT'S ENROLMENT 18 July 2010.

http://humrep.oxfordjournals.org/cgi/content/short/31/10/2219?rss=1

Source: Human Reproduction - September 18, 2016 Category: Reproduction Medicine Authors: Kleijkers, S. H. M., Mantikou, E., Slappendel, E., Consten, D., van Echten-Arends, J., Wetzels, A. M., van Wely, M., Smits, L. J. M., van Montfoort, A. P. A., Repping, S., Dumoulin, J. C. M., Mastenbroek, S. Tags: Embryology Source Type: research