"Ah, Wherefore with Infection Should he Live?": Microbial Virulence Factors in Diabetic Foot Ulceration.

"Ah, Wherefore with Infection Should he Live?": Microbial Virulence Factors in Diabetic Foot Ulceration. Curr Vasc Pharmacol. 2016 Sep 9; Authors: Vas P, Panagopoulos P, Papanas N PMID: 27633288 [PubMed - as supplied by publisher]
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research

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CONCLUSIONS: This retrospective study further supports previous evidence that acellular fish skin graft promotes wound healing in DFUs. In particular, a rapid increase in wound healing was observed during the initial 4 weeks following graft application. This study and review of the literature indicated that fish graft encourages wound healing by enabling the wound to transition from a chronic to an acute stage of healing. PMID: 31730505 [PubMed - as supplied by publisher]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
Condition:   Diabetic Foot Ulcer Intervention:   Device: Noraxon myoRESEARCH™ Software Gait Analysis Evaluation and Orthotic Sponsor:   Johns Hopkins University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
One Australian loses a limb every 3  h as a result of infected diabetic foot ulcers (DFU). This common condition accounts for substantial morbidity and mortality for affected individuals and heavy economic cost...
Source: Journal of Foot and Ankle Research - Category: Podiatry Authors: Tags: Study protocol Source Type: research
Resumo Contexto As infec ções profundas de extremidades representam um desafio para o salvamento de membro dos pacientes. Objetivos Investigar se existe concordância entre as culturas de osso e tecido profundo em pacientes com lesões tróficas de extremidades. Métodos Foi realizado um estudo retrospectivo incluindo 5 4 pacientes com lesões tróficas profundas de extremidades internados, no Complexo Hospitalar Universitário Professor Edgard Santos, Salvador (BA), Brasil. Foram incluídos todos os pacientes que realizaram culturas de lesões trófi...
Source: Jornal Vascular Brasileiro - Category: Surgery Source Type: research
r N Abstract PURPOSE: To test whether Schirmer test (ST) results are associated with topical or systemic medication and to evaluate the distribution of tear fluid quantity in a 3-min and 5-min ST. METHODS: The Gutenberg Health Study is a population-based, prospective, observational cohort study in Germany. ST was assessed in a sub-cohort of 1,999 participants. ST was performed under topical anesthesia for 5 min (ST-5) or of 3 min (ST-3). Anthropometric factors, systemic diseases, use of systemic and eye medications were recorded. We used multivariable quantile regression analysis to assess the influence o...
Source: The Ocular Surface - Category: Opthalmology Authors: Tags: Ocul Surf Source Type: research
Might a novel acellular fish skin graft offer a new effective treatment option for diabetic foot ulcers?Wounds
Source: Medscape Today Headlines - Category: Consumer Health News Tags: General Surgery Journal Article Source Type: news
Dysregulation of glucose homeostasis and elevated glucose levels are central etiologies of diabetes, a medical condition commonly encountered [1]. WHO has projected that the incidence of diabetes will continue to rise around the globe [2]. An important complication associated with diabetes is poor wound healing that may lead to ulceration, infection, and ultimately amputation [3]. Clearly, understanding the mechanisms responsible for poor diabetic wound healing is an important public health issue that needs to be addressed.
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research
AbstractPurpose of ReviewCommercialization of an automated epidermal harvesting device (CelluTome ™, Kinetic Concepts Inc., San Antonio, TX) in the last 6 years has led to numerous publications describing a growing number of clinical applications. The current article reviews this literature while summarizing outcomes.Recent FindingsA total of 20 published reports including 284 automated graft recipients have been published. Complete reepithelialization occurs in 50 –92% of recipient sites, often within 4–18 weeks of graft placement. Donor sites heal without scarring within 1–2 weeks.S...
Source: Current Dermatology Reports - Category: Dermatology Source Type: research
This study investigates the effect of high glucose and hypoxic conditions on TLR4 activation and signalling in vitro and in vivo. METHODS: Fibroblasts cultured at physiological glucose concentration (5.5 mM) were exposed to glucose concentrations from 0 mM to 25 mM, with duplicates placed in a hypoxic chamber. TLR4 inhibition was assessed in the 25 mM glucose groups. Diabetes was induced in wild type (WT) and TLR4 knockout (KO) C57BL/6 mice by intraperitoneal injection of low dose streptozocin (STZ). Hindlimb ischaemia was induced by femoral artery ligation four weeks post streptozocin, a...
Source: PubMed: Eur J Vasc Endovasc ... - Category: Surgery Authors: Tags: Eur J Vasc Endovasc Surg Source Type: research
This study investigates the effect of high glucose and hypoxic conditions on TLR4 activation and signalling in  vitro and in vivo.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
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