Characteristics and survival outcome analysis of extramedullary involvement in adult patients with t(8;21) acute myeloid leukemia

Conclusion EM-positive t(8;21) was associated with young age, leukocytosis, and c-kit mutation, and CNS was frequently involved. Allo-HCT showed a feasible outcome for EM-positive t(8;21). Teaser Extramedullary involvement in acute myeloid leukemia with t(8;21) is not a rare manifestation. Extramedullary involvement has been regarded as a poor prognostic factor although t(8;21) is a favorable-risk karyotype. We analyzed 154 patients and identified extramedullary involvement was associated with young age, leukocytosis, and c-kit mutation. Outcomes were similar after transplantation-based treatment strategy regardless of extramedullary involvement.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research