Inner Ear Regeneration: Hearing Loss, Tinnitus and Vertigo

Advanced Rejuvenation is using cutting edge therapies to stimulate hair cell (inner ear) regeneration through stem cell treatment, laser therapy and growth factor injections
Source: Disabled World - Category: Disability Tags: Tinnitus Source Type: news

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Publication date: 14 August 2018Source: Stem Cell Reports, Volume 11, Issue 2Author(s): Jill M. Goldstein, Amy J. WagersC57BL/6J and C57BL/6N inbred mice are widely, and often interchangeably, used for stem cell research; yet, these substrains harbor discrete genetic differences that can cause phenotypic disparities. In this issue of Stem Cell Reports, Morales-Hernández et al. identify one particular difference—disruption of Nicotinamide Nucleotide Transhydrogenase (Nnt)—that increases reactive oxygen exposure and impairs hematopoietic progenitor cell function in C57BL/6J, as compared to C57BL/6N, mice.
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Publication date: 14 August 2018Source: Stem Cell Reports, Volume 11, Issue 2Author(s): Tânia Perestrelo, Weitong Chen, Marcelo Correia, Christopher Le, Sandro Pereira, Ana S. Rodrigues, Maria I. Sousa, João Ramalho-Santos, Denis Wirtz
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Publication date: 14 August 2018Source: Stem Cell Reports, Volume 11, Issue 2Author(s): Daniel Simão, Marta M. Silva, Ana P. Terrasso, Francisca Arez, Marcos F.Q. Sousa, Narges Z. Mehrjardi, Tomo Šarić, Patrícia Gomes-Alves, Nuno Raimundo, Paula M. Alves, Catarina BritoSummaryBrain microenvironment plays an important role in neurodevelopment and pathology, where the extracellular matrix (ECM) and soluble factors modulate multiple cellular processes. Neural cell culture typically relies on heterologous matrices poorly resembling brain ECM. Here, we employed neurospheroids to address microenvironment re...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
We describe the first case of histologically-confirmed NEC caused by S. maltophilia accompanied by bacteremia and pneumonia after salvage chemotherapy for acute myeloid leukemia relapse following a second hematopoietic stem cell transplantation. S. maltophilia should be included as a pathogenic organism of NEC in severely immunocompromised patients to prevent a delayed diagnosis, which carries a high risk of inappropriate antimicrobial selection and fatal outcome. PMID: 30101922 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Publication date: 14 August 2018Source: Cell Reports, Volume 24, Issue 7Author(s): Quinton Smith, Bria Macklin, Xin Yi Chan, Hannah Jones, Michelle Trempel, Mervin C. Yoder, Sharon Gerecht
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 14 August 2018Source: Cell Reports, Volume 24, Issue 7Author(s): Chun-Yuan Chen, Rainer B. Lanz, Christopher J. Walkey, Wen-Hsuan Chang, Wange Lu, Deborah L. JohnsonSummaryRNA polymerase (pol) III transcribes a variety of small untranslated RNAs involved in transcription, RNA processing, and translation. RNA pol III and its components are altered in various human developmental disorders, yet their roles in cell fate determination and development are poorly understood. Here we demonstrate that Maf1, a transcriptional repressor, promotes induction of mouse embryonic stem cells (mESCs) into mesoderm. Reduced...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 14 August 2018Source: Cell Reports, Volume 24, Issue 7Author(s): Chie Kudo-Saito, Akiko Ishida, Yuji Shouya, Koji Teramoto, Tomoyuki Igarashi, Ryoko Kon, Kenji Saito, Chihiro Awada, Yamato Ogiwara, Masayoshi ToyouraSummaryImmune dysfunction is a strong factor in the resistance of cancer to treatment. Blocking immune checkpoint pathways is a promising approach to improve anti-tumor immunity, but the clinical efficacies are still limited. We previously identified follistatin-like 1 (FSTL1) as a determinant of immune dysfunction mediated by mesenchymal stromal/stem cells (MSCs) and immunoregulatory cells. He...
Source: Cell Reports - Category: Cytology Source Type: research
Conclusion: Our findings provide strong evidence that miR-9 and miR-221 can enhance the generation of cancer stem cells to yield an invasive phenotype and that overexpression of these miRNAs predicts a poor outcome for breast cancer patients.Cell Physiol Biochem 2018;48:2205 –2218
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
In conclusion, PDLSCs cultivated with this novel CHP-HA show enhanced cellular responses. We propose that CHP-HA may be a promising alternative biomaterial for periodontal tissue engineering. PMID: 30101820 [PubMed - as supplied by publisher]
Source: Journal of oral science - Category: Dentistry Tags: J Oral Sci Source Type: research
Traumatic brain injury (TBI) is a leading cause of death and disability in trauma patients. Patients with TBI frequently sustain concomitant injuries in extracranial regions. The effect of severe extracranial injury (SEI) on the outcome of TBI is controver...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
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