Inner Ear Regeneration: Hearing Loss, Tinnitus and Vertigo

Advanced Rejuvenation is using cutting edge therapies to stimulate hair cell (inner ear) regeneration through stem cell treatment, laser therapy and growth factor injections
Source: Disabled World - Category: Disability Tags: Tinnitus Source Type: news

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CONCLUSION: Putting these figures in the appropriate international context requires the acquisition of comparable data in multiple countries and is the main task of international TBI consortia. PMID: 30995953 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
Accidental falls are a leading cause of disability and death in older adults living in urban centers. However, little is known about the consequences of falls in rural communities. We aimed to assess characteristics and risk of falls in community-dwellers ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
INTRODUCTION: The co-occurrence of bipolar disorder (BD) and obsessive-compulsive disorder (OCD) seemed to be a poor prognostic factor associated with greater disability, lower social and occupational functioning, poorer treatment response, and higher suic...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
School 1: Pittsburgh OOS Pros: I really liked the special needs clinic, and the ranking is much higher than Houston. Also, I received a 60k scholarship to Pitt, making it much more affordable. I got to meet more people at Pittsburgh, and generally liked most everyone I met. Cons: I am definitely dreading the cold, dreary weather, and it is more expensive than Houston even with the scholarship. School 2: Houston OOS Pros: Cheap, and has... UPitt (OOS) vs. TX-Houston (OOS)
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Help me Decide: X vs Y Dental School Source Type: forums
PMID: 30998644 [PubMed - in process]
Source: Clinical Orthopaedics and Related Research - Category: Orthopaedics Authors: Tags: Clin Orthop Relat Res Source Type: research
Scleroderma is one of the main clinical features of chronic graft-versus-host disease (cGVHD), in which donor immune cells react against host tissues after allogeneic hematopoietic stem cell transplant. It has been reported that interferon (IFN)- γ released by donor T cells promotes infiltration of donor T cells themselves into the skin, and mediates production of transforming growth factor (TGF)-β from macrophages in the pathogenesis of sclerodermatous cGVHD. To investigate the roles of host keratinocytes, which are the targets for donor T cells, in skin fibrosis of cGVHD, we established a new murine model of s...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research
Previous studies revealed that cutaneous manifestations of acute graft-versus-host disease (aGVHD) patients, in which donor immune cells react against host tissues after allogeneic hematopoietic stem cell transplant, are mediated by CD8 T cells. Cutaneous aGVHD is histologically characterized by reduced number of epidermal Langerhans cells (LCs). To investigate the roles of LCs, we analyzed a murine model using transgenic mice that express membrane-bound chicken ovalbumin under control of a keratin 14 promoter (K14-mOVA Tg mice), which develop aGVHD-like mucocutaneous disease after OVA-specific CD8 T cell (OT-I cell) transfer.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research
It remains unclear whether basal cell carcinomas (BCCs) originate from the stem cells in the hair follicle bulge or inter-follicular epithelial (IFE) regions. To explore the lineage derivation of BCC tumors, we applied single-cell RNA sequencing to 56219 cells isolated from 4 BCCs and 2 normal skin samples, profiling tumor keratinocyte, immune, stromal, melanocyte and endothelial cell subpopulations. Pseudotime trajectories of keratinocyte and fibroblast clusters displayed a common origin of normal cells, then a bifurcation into two branches in BCCs.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Carcinogenesis and Cancer Genetics Source Type: research
Cancer persister cells survive cytotoxic therapies by entering a drug-tolerant, pro-survival cell state governed by poorly understood nongenetic mechanisms. Persister cells have been observed in a wide range of tumor types and are known to exhibit tolerance to targeted therapies and chemotherapies. Key characteristics of persister cells include reversible drug-tolerance, quiescence/slow proliferation, low genome-wide H3K4me3 marks, cancer stem cell and EMT gene expression patterns, and cross resistance to other cytotoxic drugs.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Carcinogenesis and Cancer Genetics Source Type: research
Objectives: To determine whether long term (>48 months) symptomatic vertigo control is sustained in patients with Menière's disease from a previous comparative trial of intratympanic methylprednisolone versus gentamicin, and if the two treatments remain nonsignificantly different at long-term follow-up. Study Design: Mail survey recording vertigo frequency in the previous one and six months, further intratympanic treatment received, and validated symptom questionnaires. Setting: Outpatient hospital clinic setting. Patients: Adult patients with definite unilateral refractory Menière's disease, wh...
Source: Otology and Neurotology - Category: ENT & OMF Tags: VESTIBULAR DISORDERS Source Type: research
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