Potential role of microRNA-10b down-regulation in cardiomyocyte apoptosis in aortic stenosis patients

In conclusion, myocardial down-regulation of miR-10b may be involved in increased cardiomyocyte apoptosis in AS patients, probably through Apaf-1 upregulation, contributing to cardiomyocyte damage and to the development of heart failure.

Source: Clinical Science - September 12, 2016 Category: Biomedical Science Authors: Gallego, I., Beaumont, J., Lopez, B., Ravassa, S., Jose Gomez-Doblas, J. J., Moreno, M. U. U., Valencia, F., de Teresa, E., Diez, J., Gonzalez, A. Tags: PublishAheadOfPrint Source Type: research