Shortage Of Organs For Transplantation -- Is More Research on Human-Animal Chimeras the Right Approach?

This piece was originally published on Bionews and co-authored with Giulia Cavaliere. You can read the original piece here. It is time to discuss, once again, the lifting of a moratorium on research. We are not talking about the CRISPR genome-editing moratorium, but about the 20 August announcement by the US National Institutes of Health (NIH) to lift the moratorium on research involving chimeric human/non-human embryos. The use of federal funds for this kind of research had been previously banned by the NIH in September 2015. Although it does not state it explicitly, the NIH announcement seems to have been triggered by Harvard professor George Church's research on growing humanised organ models in non-human animals, namely pigs. Insoo Hyun, a bioethicist at the Case Western Reserve School of Medicine in Cleveland, Ohio, followed with a perspective piece in PLOS Biology, stating that the benefits of this kind of research are so great that we should no longer hesitate to fund it. The piece by Hyun addresses traditional concerns in animal ethics, such as safety, the moral status of the non-human animal (in this case, the human/non-human chimera) and the exploitation of non-human animals in research. We agree with his precautionary stance which, is consistent with the existent ethical standards for chimera research developed by the Internal Society for Stem Cell Research in 2007, and with more emphasis on animal welfare than on speculative concerns about moral humanization...
Source: Science - The Huffington Post - Category: Science Source Type: news

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Authors: Achmat G, Leach L, Onagbiye SO Abstract BACKGROUND: Cardiometabolic disease (CMD) risk factors have reached epidemic proportions, with many people at risk of premature disability and death. There is insufficient data regarding the prevalence of CMD risk factors among firefighters in the Western Cape Province of South Africa. The purpose of this study was to examine the prevalence of CMD risk factors among South African firefighters in the Western Cape Province. Additional outcomes were to determine the relationship between BMI and CMD risk factors among firefighters. METHODS: A total of 219 healthy mal...
Source: Journal of Sports Medicine and Physical Fitness - Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research
Those who could benefit from activity to avoid disabilities are told not to get up on their own: “They’re not letting me get up out of bed.”
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news
by Drew Rosielle (@drosielle)This is the second in a series of several posts about many aspects of my current thinking about opioids.The first post is here:Part 1 – Introduction, General Disclaimers, Hand-Wringing, and a Hand-Crafted Graph.Over-prescribing fueled the current drug overdose epidemic, and many of us who thought we were stamping out needless suffering contributed to the epidemic.A lot of what I read and believed about opioids early on in my career was wrong.I ’m old enough to remember those heady days in which there was a pretty large and ‘successful’ movement in American medicine to gr...
Source: Pallimed: A Hospice and Palliative Medicine Blog - Category: Palliative Care Tags: opioids pain rosielle The profession Source Type: blogs
 In the first full episode of Not Crazy, we learn a little more about the new co-host, Jackie, and her history with chronic illness and depression. Gabe rants about person-first language and how nitpicking verbiage is distracting from more pressing matters in the lives of those living with mental illness.  Overall, we decide that “crazy” is not a dirty word and there are other, more time-sensitive, things we should be focusing on that can benefit the mental health community.  SUBSCRIBE &REVIEW About The Hosts Gabe Howard is an award-winning writer and speaker who lives with bipolar disorder...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Not Crazy Podcast Self-Help Stigma Source Type: blogs
In conclusion, older adults exhibited decreased markers of UPR activation and reduced coordination with autophagy and SC-associated gene transcripts following a single bout of unaccustomed resistance exercise. In contrast, young adults demonstrated strong coordination between UPR genes and key regulatory gene transcripts associated with autophagy and SC differentiation in skeletal muscle post-exercise. Taken together, the present findings suggest a potential age-related impairment in the post-exercise transcriptional response that supports activation of the UPR and coordination with other exercise responsive pathways (i.e....
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract Cardiovascular diseases (CVDs) are the leading cause of premature death and disability in humans and their incidence is on the rise globally. Given their substantial contribution towards the escalating costs of health care, they also generate a high socio-economic burden in the general population. The underlying pathogenesis and progression associated with nearly all CVDs is predominantly of atherosclerotic origin that leads to the development of coronary artery disease, cerebrovascular disease, venous thromboembolism and, peripheral vascular disease, subsequently causing myocardial infarction, cardiac ar...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
ConclusionMore effective structural healthcare policies shall be planned at a worldwide scale for contrasting the epidemics of LDL-C attributable heath loss.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Diabetes has grown to become one of the most important public health concerns of our time. A review by the Harvard T.H. Chan School of Public Health has shown that the number of affected people has quadrupled in the last three decades. Type 2 diabetes (T2D), a type of diabetes traditionally occurring in adults and associated with obesity and a sedentary lifestyle, is now the ninth leading cause of death worldwide. It therefore comes as no surprise that this rapidly emerging epidemic is giving rise to a profusion of diabetes-related complications. What are the usual diabetes-related complications? As diabetes is a systemic ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Diabetes Health Source Type: blogs
BACK pain is the leading global cause of disability worldwide, according to the World Health Organisation. A new app aims to end the nationwide epidemic. How does it work?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
APA on Wednesday joined six other physician and health professional organizations in calling for action to address the public health epidemic of firearm-related injury and death.“Our nation is in the midst of an epidemic of firearm-related injuries and deaths, and we must treat this as a public health crisis,” APA President Bruce Schwartz, M.D., said in apress release. “We see the long-lasting mental health impact firearm-related violence and injury has on our patients every day, and it is time for us to come together as a nation to address this epidemic.”The call to action was published yesterday i...
Source: Psychiatr News - Category: Psychiatry Tags: Annals of Internal Medicine background checks Bruce Schwartz extreme risk protection orders firearm death firearm injury high-capacity magazines public health Saul Levin Source Type: research
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