Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transit

Conclusions The most abundant FSPs are of human origin. Rapid transit through the colon and/or decreased (possibly bacterial) proteolytic degradation increases their faecal concentration and could contribute to visceral hypersensitivity in patients with IBS-D. ClinicalTrials.gov NCT00745004.
Source: Gut - Category: Gastroenterology Authors: Tags: Drugs: gastrointestinal system, Pancreas and biliary tract, Diarrhoea, Irritable bowel syndrome, Open access Neurogastroenterology Source Type: research