Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transit
Conclusions
The most abundant FSPs are of human origin. Rapid transit through the colon and/or decreased (possibly bacterial) proteolytic degradation increases their faecal concentration and could contribute to visceral hypersensitivity in patients with IBS-D.
ClinicalTrials.gov
NCT00745004.
Source: Gut - Category: Gastroenterology Authors: Tooth, D., Garsed, K., Singh, G., Marciani, L., Lam, C., Fordham, I., Fields, A., Banwait, R., Lingaya, M., Layfield, R., Hastings, M., Whorwell, P., Spiller, R. Tags: Drugs: gastrointestinal system, Pancreas and biliary tract, Diarrhoea, Irritable bowel syndrome, Open access Neurogastroenterology Source Type: research
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