Wnt Pathway Inhibition by an LRP6 Bispecific dAb

This article demonstrates the inhibition of a key oncogenic receptor, intractable to mAb inhibition due to multiple independent ligand interaction sites, using an innovative dAb approach. Mol Cancer Res; 14(9); 859–68. ©2016 AACR.

Source: Molecular Cancer Research - September 12, 2016 Category: Cancer & Oncology Authors: Jackson, H., Granger, D., Jones, G., Anderson, L., Friel, S., Rycroft, D., Fieles, W., Tunstead, J., Steward, M., Wattam, T., Walker, A., Griggs, J., Al-Hajj, M., Shelton, C. Tags: Signal Transduction Source Type: research