Comparison of plasma amino acid profile-based index and CA125 in the diagnosis of epithelial ovarian cancers and borderline malignant tumors

AbstractBackgroundWe previously developed a new plasma amino acid profile-based index (API) to detect ovarian, cervical, and endometrial cancers. Here, we compared API to serum cancer antigen 125 (CA125) for distinguishing epithelial ovarian malignant tumors from benign growths.MethodsAPI and CA125 were measured preoperatively in patients with ovarian tumors, which were later classified into 59 epithelial ovarian cancers, 21 epithelial borderline malignant tumors, and 97 benign tumors including 40 endometriotic cysts. The diagnostic accuracy and cutoff points of API were evaluated using receiver operating characteristic (ROC) curves.ResultsThe area under the ROC curves showed the equivalent performance of API and CA125 to discriminate between malignant/borderline malignant and benign tumors (both 0.77), and API was superior to CA125 for discrimination between malignant/borderline malignant lesions and endometriotic cysts (API, 0.75 vs. CA125, 0.59;p 
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research

Related Links:

Publication date: Available online 21 May 2020Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Tomasz Szaflik, Beata Smolarz, Hanna Romanowicz, Magdalena Bryś, Ewa Forma, Krzysztof Szyłło
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Publication date: Available online 30 May 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Kevin C. Lee, Sung-Kiang Chuang
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Publication date: Available online 30 May 2020Source: Pharmacological ResearchAuthor(s): Ling Wang, Ke Deng, Liang Gong, Liang Zhou, Sapna Sayed, Huan Li, Qi Sun, Zijie Su, Zhongyuan Wang, Shanshan Liu, Huifang Zhu, Jiaxing Song, Desheng Lu
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 31 May 2020Source: Pharmacology &TherapeuticsAuthor(s): Jie Yu, Bingling Zhong, Qingwen Xiao, Lida Du, Ying Hou, Hong-Shuo Sun, Jin-Jian Lu, Xiuping Chen
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 31 May 2020Source: Pharmacology &TherapeuticsAuthor(s): Kevin M. Levine, Kai Ding, Lyuqin Chen, Steffi Oesterreich
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: August 2020Source: Biomedicine &Pharmacotherapy, Volume 128Author(s): Qi Chen, Huachao Xu, Jiang Zhu, Kehai Feng, Changlu Hu
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: August 2020Source: Biomedicine &Pharmacotherapy, Volume 128Author(s): Celso Alves, Eurico Serrano, Joana Silva, Carlos Rodrigues, Susete Pinteus, Helena Gaspar, Luis M. Botana, Maria C. Alpoim, Rui Pedrosa
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 31 May 2020Source: PhytomedicineAuthor(s): Yi-Wen Hsu, Hsin-Yuan Chen, Yi-Fen Chiang, Li-Chun Chang, Po-Han Lin, Shih-Min Hsia
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 30 May 2020Source: PhytomedicineAuthor(s): Weihuan Huang, Yeyin Liang, Hau Yin Chung, Guocai Wang, Jim Junhui Huang, Yaolan Li
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: An approach to standardise current dose modification schemes in young children is proposed. The consented concept takes individual pharmacokinetic characteristics into account and involves adaptation of both the dose and the infusion duration potentially improving the safety of doxorubicin administration. PMID: 32466789 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
More News: Borderline Tumor | Cancer | Cancer & Oncology | Cervical Cancer | Endometrial Cancer | Endometriosis | Epithelial Cancer | Ovarian Cancer | Ovaries | Study