Modified FOLFOX6 With or Without Radiation Versus Fluorouracil and Leucovorin With Radiation in Neoadjuvant Treatment of Locally Advanced Rectal Cancer: Initial Results of the Chinese FOWARC Multicenter, Open-Label, Randomized Three-Arm Phase III Trial [Gastrointestinal Cancer]

Conclusion mFOLFOX6-based preoperative chemoradiotherapy results in a higher pCR rate than fluorouracil-based treatment. Perioperative mFOLFOX6 alone had inferior results and a lower pCR rate than chemoradiotherapy but led to a similar downstaging rate as fluorouracil-radiotherapy, with less toxicity and fewer postoperative complications.

http://jco.ascopubs.org/cgi/content/short/34/27/3300?rss=1

Source: Journal of Clinical Oncology - September 12, 2016 Category: Cancer & Oncology Authors: Deng, Chi, Lan, Wang, Chen, Cui, Chen, Cao, Wei, Peng, Huang, Cai, Zhao, Huang, Xu, Zhou, Wei, Zhang, Zheng, Huang, Zhou, Cai, Kang, Huang, Peng, Ren, Wang Tags: Clinical Trials, Surgery, Radiation, Chemotherapy, Combined Modality Gastrointestinal Cancer Source Type: research