Lower Placental Leptin Promoter Methylation in Association with Fine Particulate Matter Air Pollution during Pregnancy and Placental Nitrosative Stress at Birth in the ENVIRONAGE Cohort

Conclusions: LEP methylation status in the placenta was negatively associated with PM2.5 exposure during the second trimester, and with placental 3-NTp, a marker of oxidative/nitrosative stress. Additional research is needed to confirm our findings and to assess whether oxidative/nitrosative stress might contribute to associations between PM2.5 and placental epigenetic events. Potential consequences for health during the neonatal period and later in life warrant further exploration. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Saenen ND, Vrijens K, Janssen BG, Roels HA, Neven KY, Vanden Berghe W, Gyselaers W, Vanpoucke C, Lefebvre W, De Boever P, Nawrot TS. Lower Placental Leptin Promoter Methylation in Association with Fine Particulate Matter Air Pollution during Pregnancy and Placental Nitrosative Stress at Birth in the ENVIRONAGE Cohort. Environ Health Perspect; http://dx.doi.org/10.1289/EHP38 Received: 29 February 2016 Revised: 13 August 2016 Accepted: 18 August 2016 Published: 13 September 2016 Note to readers with disabilities: EHP strives t...
Source: EHP Research - Category: Environmental Health Authors: Tags: Children's Health Source Type: research

Related Links:

AbstractPurpose of ReviewThis paper seeks to review the important musculoskeletal issues that arise for pregnant and postpartum women. It outlines the background, diagnosis, and management of these musculoskeletal issues; reviews the existing and recent literature; and offers clinical opinions from the perspective of women ’s health PM&R physicians.Recent FindingsExisting and recent literature on pelvic girdle pain, lumbosacral back pain, pubic symphysis separation, transient osteoporosis, rectus diastasis, and postpartum neuropathy offer some new insights on management, which is often context-dependent. Management r...
Source: Current Physical Medicine and Rehabilitation Reports - Category: Rehabilitation Source Type: research
This study examined the contribution of long-term use of Lipiodol capsules, as a supplement to iodized salt to the control of iodine deficiency disorders among women in Xinjiang of China. A total of 1220 women (women of childbearing age who were neither pregnant nor lactating, pregnant women, and lactating women) across Kashgar, Aksu, Turpan, and Yili Prefectures were surveyed in 2017. Lipiodol capsules were administered twice yearly in Kashgar and once yearly in Aksu and Turpan, but not in Yili. Urinary iodine concentration (UIC), FT3, FT4, TgAb, TPOAb, and thyroid volume values were assessed. All the women in the four ar...
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research
Discussion Herpes simplex virus (HSV) infections are common with an estimated 50% of the US population being infected by age 30, and with latent infection harboring in the trigeminal nerve in 100% of people by age 60 years. HSV infections can cause a vesicular or pustular skin rash that is painful, burning or pruritic and also flu-like symptoms with fever, chills, headache, and fatigue. HSV can also be asymptomatic. To laymen, herpes simplex viruses cause “cold sores,” but to health care personnel, herpes causes many systemic infections including eczema herpeticum, folliculitis, herpes gladiatorum, whitlow, e...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Purpose of review To review the recent literature on the burden of eating disorders in terms of mortality, disability, quality of life, economic cost, and family burden, compared with people without an eating disorder. Recent findings Estimates are that yearly over 3.3 million healthy life years worldwide are lost because of eating disorders. In contrast to other mental disorders, in anorexia nervosa and bulimia nervosa years lived with disability (YLDs) have increased. Despite treatment advances, mortality rates of anorexia nervosa and bulimia nervosa remain very high: those who have received inpatient treatment for ...
Source: Current Opinion in Psychiatry - Category: Psychiatry Tags: EATING DISORDERS: Edited by Hans W. Hoek and Anna Keski-Rahkonen Source Type: research
CONCLUSIONS: Pilates exercises can be recommended as an effective and safe method for increasing lumbopelvic stabilization, reducing pain and disability, improving physical mobility and sleep problems in pregnant women with LBP. PMID: 32986655 [PubMed - as supplied by publisher]
Source: Journal of Back and Musculoskeletal Rehabilitation - Category: Orthopaedics Tags: J Back Musculoskelet Rehabil Source Type: research
We describe the biomechanical changes that may lead to sacroiliac dysfunction during pregnancy, pubic symphysis dysfunction, diastasis recti in the peripartum period, and pregnancy-related low back pain. Our focus was to examine the impact of exercise on each condition.Recent FindingsWe consolidated updated guidelines for physical activity throughout pregnancy, explored whether exercise is effective for stabilizing the low back and pelvic girdle in pregnant and postpartum patients as well as reviewed the absolute and relative contraindications to physical activity during pregnancy.SummaryPLBP and PPGP stem from multiple et...
Source: Current Physical Medicine and Rehabilitation Reports - Category: Rehabilitation Source Type: research
Contributors : Faycal Guedj ; Ashley E Siegel ; Jeroen L Pennings ; Fatimah Alsebaa ; Lauren J Massingham ; Umadevi Tantravahi ; Diana W BianchiSeries Type : Expression profiling by arrayOrganism : Homo sapiensDown syndrome (DS), a genetic condition leading to intellectual disability, is characterized by triplication of human chromosome 21. Neuropathological hallmarks of DS include abnormal central nervous system development that manifests during gestation and extends throughout life. As a result, newborns and adults with DS exhibit cognitive and motor deficits and fail to meet typical developmental and lack independent li...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Contributors : Faycal Guedj ; Ashley E Siegel ; Jeroen L Pennings ; Fatimah Alsebaa ; Lauren J Massingham ; Umadevi Tantravahi ; Diana W BianchiSeries Type : Expression profiling by arrayOrganism : Mus musculusDown syndrome (DS), a genetic condition leading to intellectual disability, is characterized by triplication of human chromosome 21. Neuropathological hallmarks of DS include abnormal central nervous system development that manifests during gestation and extends throughout life. As a result, newborns and adults with DS exhibit cognitive and motor deficits and fail to meet typical developmental and lack independent li...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
This article also contains multiple policy alternatives, interest group involvement related to pregnancy anti-discrimination policy, unintended consequences of policy implementation as well as potential issues with enforcement of the Kentucky Pregnant Workers Act. PMID: 32962517 [PubMed - as supplied by publisher]
Source: Policy, Politics, and Nursing Practice - Category: Nursing Authors: Tags: Policy Polit Nurs Pract Source Type: research
MONDAY, Sept. 21, 2020 -- Many women with severe migraines don't want to get pregnant because of concerns about their headaches, a new study finds. Migraine, one of the world's leading causes of disability, particularly affects women of childbearing...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
More News: Child Development | Children | Disability | Drugs & Pharmacology | Environment Agency | Environmental Health | Health | Hormones | OBGYN | Perinatology & Neonatology | Pregnancy | Toxicology