Patients with Down syndrome and congenital heart disease: survival is improving, but challenges remain

Down syndrome (DS) is one of the most common chromosomal abnormalities. The incidence of DS at birth in developed countries has remained relatively stable over the last 20 years, at approximately 1 per 1000 live births. DS is associated with a number of congenital defects and is also at increased risk of conditions that may develop later in life, and thus requires multidisciplinary care and close surveillance. Congenital heart disease (CHD) is present in 35%–50% of patients and is haemodynamically significant in two-thirds.1 Early diagnosis and treatment in expert centres are essential for improving short-term and long-term outcomes and avoiding important complications, such as the development of pulmonary arterial hypertension (PAH). Pulmonary arterial hypertension related to congenital heart disease in Down syndrome The CHD most commonly encountered in DS is atrioventricular septal defects, ventricular septal defects and atrial septal defects.1 Large post-tricuspid defects...
Source: Heart - Category: Cardiology Authors: Tags: Congenital heart disease, Drugs: cardiovascular system, Hypertension, Interventional cardiology, Epidemiology Editorials Source Type: research

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Authors: Bergland OU, Søraas CL, Larstorp ACK, Halvorsen LV, Hjørnholm U, Hoffman P, Høieggen A, Fadl Elmula FEM Abstract PURPOSE: The blood pressure (BP) lowering effect of renal sympathetic denervation (RDN) in treatment-resistant hypertension shows variation amongst the existing randomised studies. The long-term efficacy and safety of RDN require further investigation. For the first time, we report BP changes and safety up to 7 years after RDN, compared to drug adjustment in the randomised Oslo RDN study. MATERIALS AND METHODS: Patients with treatment-resistant hypertension, defined...
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
Authors: Zhang W, Xu JZ, Lu XH, Li H, Wang D, Wang JG Abstract PURPOSE: We hypothesise that dietary sodium intake interacts with serum uric acid to influence blood pressure (BP) in children and adolescents. In the present study, we investigated ambulatory BP in relation to hyperuricaemia, dietary sodium intake and their interaction in children and adolescents with hypertension. MATERIALS AND METHODS:  A total of 616 study participants were 10-24 years old and had primary hypertension diagnosed after admission in a specialised inpatient ward. Ambulatory BP monitoring was performed during hospitalisat...
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
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Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
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Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
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Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Publication date: January 2021Source: Biomedical Signal Processing and Control, Volume 63Author(s): Irene Hidalgo-De la Guía, Elena Garayzábal, Pedro Gómez-Vilda, Daniel Palacios-Alonso
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
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Publication date: Available online 9 October 2020Source: Medical Journal Armed Forces IndiaAuthor(s): Shreyans Darla, Deepa Bhat
Source: Medical Journal Armed Forces India - Category: General Medicine Source Type: research
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Source: Chinese Journal of Integrative Medicine - Category: Internal Medicine Source Type: research
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Source: Neurological Sciences - Category: Neurology Source Type: research
More News: Atrial Septal Defect | Atrioventricular Septal Defect | Cardiology | Cardiovascular | Down's Syndrome | Epidemiology | Heart | Heart Disease | Hole in the Heart | Hypertension | Ventricular Septal Defect