Patients with Down syndrome and congenital heart disease: survival is improving, but challenges remain

Down syndrome (DS) is one of the most common chromosomal abnormalities. The incidence of DS at birth in developed countries has remained relatively stable over the last 20 years, at approximately 1 per 1000 live births. DS is associated with a number of congenital defects and is also at increased risk of conditions that may develop later in life, and thus requires multidisciplinary care and close surveillance. Congenital heart disease (CHD) is present in 35%–50% of patients and is haemodynamically significant in two-thirds.1 Early diagnosis and treatment in expert centres are essential for improving short-term and long-term outcomes and avoiding important complications, such as the development of pulmonary arterial hypertension (PAH). Pulmonary arterial hypertension related to congenital heart disease in Down syndrome The CHD most commonly encountered in DS is atrioventricular septal defects, ventricular septal defects and atrial septal defects.1 Large post-tricuspid defects...
Source: Heart - Category: Cardiology Authors: Tags: Congenital heart disease, Drugs: cardiovascular system, Hypertension, Interventional cardiology, Epidemiology Editorials Source Type: research

Related Links:

Publication date: Available online 21 February 2020Source: NeurocomputingAuthor(s): Xuchu Wang, Suiqiang Zhai, Yanmin NiuAbstractAccurate left ventricle landmark localization in cardiac MRI plays a vital role in computer-aided diagnosis of heart disease. Typical classification models hardly deal with artifacts and low discrimination of landmark regions by using only local image information, while regression models suffer from ambiguity between random samples and label, also the imbalance of samples. To overcome this limitation, this paper proposes a left ventricle landmark localization and identification method in cardiac ...
Source: Neurocomputing - Category: Neuroscience Source Type: research
CONCLUSIONS: Not all interventional procedures result in a mortality benefit. Medical therapy alone increases survival in many cardiac diseases. PMID: 32083425 [PubMed - as supplied by publisher]
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
CONCLUSIONS: The assessment of mitral apparatus in acute phase of MI can be most useful to determine the change of the degree of MR long-term post MI. Although LV remodelling itself contributes to IMR, this influence is directly dependent on alterations in mitral geometry. PMID: 32083424 [PubMed - as supplied by publisher]
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
Authors: Nuotio J, Suvila K, Cheng S, Langén V, Niiranen T Abstract Observational and interventional studies have unequivocally demonstrated that "present", i.e. single-occasion, blood pressure is one of the key determinants of cardiovascular disease risk. Over the past two decades, however, numerous publications have suggested that longitudinal blood pressure data and assessment of long-term blood pressure exposure provide incremental prognostic value over present blood pressure. These studies have used several different indices to quantify the overall exposure to blood pressure, such as time-aver...
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
Discussion IAB is a rather frequent finding in the general population. IAB is a risk factor for AF and is associated with an increased risk of stroke or TIA independently of associated AF. Key messagesBoth partial and advanced interatrial block are associated with increased risk of atrial fibrillation in the general population.Advanced interatrial block is an independent risk factor for stroke and transient ischemic attack.The clinical significance of interatrial block is dependent on the subtype classification. PMID: 32077319 [PubMed - as supplied by publisher]
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
Conclusions Surufatinib demonstrated promising efficacy with a tolerable and manageable safety profile for patients with locally advanced or metastatic MTC, RAI-refractory DTC, or locally advanced, unresectable recurrences unable to receive RAI. PMID: 32075524 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
ConclusionsThere are elevated levels of risk for CVD in some athletes, primarily football players. Lifestyle behaviours associated with elite athleticism, particularly football linemen potentially expose players to greater metabolic and CVD risk, which is not completely offset by sport participation.
Source: Journal of Science and Medicine in Sport - Category: Sports Medicine Source Type: research
In conclusion, our data suggests that progression to kidney disease might not be a major concern in women after preeclampsia within 18 years postpartum.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Publication date: January 2020Source: Pregnancy Hypertension, Volume 19Author(s): Zain Awamleh, Victor K.M. HanAbstractPreeclampsia (PE) and intrauterine growth restriction (IUGR) are pregnancy complications resulting from abnormal placental development. As epigenetic regulators, microRNAs can regulate placental development and contribute to the disease pathophysiology by influencing the expression of genes involved in placental development or disease. Our previous study revealed an increase in miR-210-5p expression in placentae from patients with early-onset pregnancy complications and identified candidate gene targets fo...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
ConclusionWe feel these data are suggestive of increased on-aspirin platelet (re-)activity, as measured by the PFA-200 and the VerifyNow, in non-pregnant carriers of a FII-mutation, but not in carriers of FVL-mutation. Interestingly, this increased on-aspirin platelet (re-)activity is present in spite of low sTxB2 levels.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
More News: Atrial Septal Defect | Atrioventricular Septal Defect | Cardiology | Cardiovascular | Down's Syndrome | Epidemiology | Heart | Heart Disease | Hole in the Heart | Hypertension | Ventricular Septal Defect